L7252

Lactalbumin

• CAS Number: 9013-90-5
• EC Number: 232-750-1
• MDL number: MFCD00130492
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: bovine
• Quality Level: 200
• form: powder
• technique(s): cell culture | insect: suitable
• UniProt accession no.: P00711
• storage temp.: 2-8°C
• Gene Information: bovine ... LALBA(281894)

Description

General description

α-Lactalbumin is a small, globular, whey protein that has been found in all milk studied to date. It is a metalloprotein of approximately 14 kDa produced in the mammary glands.[1]

Application

α-Lactalbumin was used in a cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome.[2]

Lactalbumin has also been used in rearing anopheline mosquitoes.[3]

Biochem/physiol Actions

α-Lactalbumin consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form.[4] α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex. [5]^[6] The mature protein consists of 123 amino acid residues (14 kDa), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four a-helices and a triple stranded antiparallel β-sheet.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)