Oleoyl-L-α-lysophosphatidic acid sodium salt

≥98%, solid

1-Oleoyl-sn-glycerol 3-phosphate sodium salt, LPA sodium salt, 3-sn-Lysophosphatidic acid, 1-oleoyl sodium salt
Empirical Formula (Hill Notation):
C21H41O7P · xNa+
CAS Number:
Molecular Weight:
436.52 (free acid basis)
MDL number:
PubChem Substance ID:

Quality Level







storage temp.


SMILES string




InChI key


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General description

Lysophosphatidic acid (LPA) is an essential metabolite for membrane biosynthesis. LPA interacts with the G protein-coupled receptors (GPCRs), called the LPA receptor and mediates signaling. Oleoyl-L-α-lysophosphatidic acid activates the receptor LPA4. In keratinocytes, oleoyl-L-α-lysophosphatidic acid promotes growth to some extent.


Oleoyl-L-α-lysophosphatidic acid sodium salt has been used:
  • for the activation of Ras homolog gene family, member A (RhoA) and expression of claudin-1 in human breast cancer epithelial cell line
  • in RH7777 cells for cyclic adenosine monophosphate (cAMP) accumulation assay and calcium mobilisation assay
  • in vitro luciferase assay and live-cell imaging


1, 5, 25 mg in glass bottle

Biochem/physiol Actions

Endogenous agonist for LPA1 and LPA2 receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Hygroscopic, photosensitive

Preparation Note

Prepared by the action of phospholipase A on L-α-phosphatidic acid, dioleoyl.


13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Biological roles of lysophosphatidic acid signaling through its production by autotaxin
Okudaira S, et al.
Biochimie, 92(6), 698-706 (2010)
A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
Azad T, et al.
Nature Communications, 9(1), 1061-1061 (2018)
Phosphatidic acid has a potential to promote hair growth in vitro and in vivo, and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells
Takahashi T, et al.
The Journal of Investigative Dermatology, 121(3), 448-456 (2003)
F N van Leeuwen et al.
Biochemical Society transactions, 31(Pt 6), 1209-1212 (2003-12-04)
LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three...
T Nishizaki et al.
Brain research. Molecular brain research, 50(1-2), 121-126 (1997-12-24)
The effect of lysophosphatidic acid (lysoPA) on acetylcholine (ACh)-evoked currents was examined using normal and mutant Torpedo nicotinic ACh receptors expressed in Xenopus oocytes. LysoPA enhanced ACh-evoked currents in a washing time- and dose-dependent manner at concentrations of 0.1-3 microM...
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