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L8000

L-Leucine

≥98% (HPLC), suitable for ligand binding assays

Synonym(s):

(S)-2-Amino-4-methylpentanoic acid

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Pack SizeSKUAvailabilityPrice
25 g

Available to ship TODAYfromMILWAUKEE

$38.70
50 g

Available to ship TODAYfromMILWAUKEE

$72.90
100 g

Available to ship TODAYfromMILWAUKEE

$114.00
250 g

Available to ship TODAYfromMILWAUKEE

$251.00
1 kg

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$767.00

About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-522-0
MDL number:
Beilstein/REAXYS Number:
1721722

$38.70


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Product Name

L-Leucine, reagent grade, ≥98% (HPLC)

grade

reagent grade

Quality Level

assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

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This Item
L8912PHR1105W329703
form

powder

form

powder

form

-

form

-

grade

reagent grade

grade

-

grade

certified reference material, pharmaceutical secondary standard

grade

FG, Kosher

technique(s)

ligand binding assay: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

assay

≥98% (HPLC)

assay

98.5-101.0%

assay

-

assay

99%

color

white to off-white

color

white

color

-

color

-

impurities

isoleucine and methionine, essentially free

impurities

endotoxin, tested

impurities

-

impurities

-


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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Related Content

Product Information Sheet


Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
Dr. Victor Prisk
The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)



Global Trade Item Number

SKUGTIN
L8000-1KG04061833965801
L8000-100G04061833965795
L8000-250G04061835367214
L8000-25G04061835367221
L8000-50G04061835367238

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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