L8000

Sigma-Aldrich

L-Leucine

reagent grade, ≥98% (HPLC)

Synonym(s):
(S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein/REAXYS Number:
1721722
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

grade

reagent grade

assay

≥98% (HPLC)

form

powder

application(s)

ligand binding assay: suitable
peptide synthesis: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Packaging

25, 50, 100, 250 g in poly bottle
1 kg in poly bottle

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
Xiaodi Fan
Journal of Translational Medicine (2015)
Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)
Dr. Victor Prisk
The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
William I A Haynes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4804-4814 (2013-03-15)
The identification of a hyperdirect cortico-subthalamic nucleus connection highlighted the important role of the subthalamic nucleus (STN) in regulating behavior. However, this pathway was shown primarily from motor areas. Hyperdirect pathways associated with cognitive and motivational cortical regions are particularly...

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