L8141

Sigma-Aldrich

Anti-Human Lambda Light Chain (Bound and Free) antibody produced in rabbit

whole antiserum

MDL number:
NACRES:
NA.46

biological source

rabbit

Quality Level

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

application(s)

quantitative precipitin assay: 1.5

conjugate

unconjugated

shipped in

dry ice

storage temp.

−20°C

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General description

Lambda (λ) light chain has an amino-terminal variable region and carboxy-terminal constant region. λ chain is biologically important and constitutes 30 to 40% of human immunoglobulin (Ig) molecules. The human λ locus is mapped to human chromosome 22.

Biochem/physiol Actions

Immunoglobulins (Ig) are produced by the B cells and play crucial role in host humoral immune response. A typical immunoglobulin consists of two heavy chains and two light chains. The two light chains are either κ or the λ chain. The B cells express one type of light chain during their life time.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

B-cell development
Hematology (2018)
Structural and functional properties of human lambda-light-chain variable-region subgroups.
A Solomon et al.
Clinical and diagnostic laboratory immunology, 2(4), 387-394 (1995-07-01)
Jerry A Katzmann et al.
Clinical chemistry, 48(9), 1437-1444 (2002-08-27)
The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and is especially important in light-chain diseases, such as light-chain myeloma, primary systemic amyloidosis, and light-chain-deposition disease. These diseases are more...

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