MilliporeSigma
All Photos(4)

Documents

L8912

Sigma-Aldrich

L-Leucine

from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sign Into View Organizational & Contract Pricing

Synonym(s):
(S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein:
1721722
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

biological source

non-animal source

Quality Level

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

optical activity

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl
[α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

>300 °C (lit.)

solubility

1 M HCl: 50 mg/mL

cation traces

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: <0.02%
heavy metals: ≤10 ppm

application(s)

peptide synthesis
pharmaceutical (small molecule)

functional group

amine
carboxyl

storage temp.

room temp

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
61819L800076526
L-Leucine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

L8912

L-Leucine

-
L-Leucine BioUltra, &#8805;99.5% (NT)

Sigma-Aldrich

61819

L-Leucine

Premium Grade
L-Leucine reagent grade, &#8805;98% (HPLC)

Sigma-Aldrich

L8000

L-Leucine

Essential Grade
L-Leucine certified reference material, TraceCERT&#174;, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

76526

L-Leucine

-
form

powder

form

powder or crystals

form

powder

form

-

optical activity

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl, [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

optical activity

[α]20/D +15.5±0.5°, c = 5% in 5 M HCl

optical activity

-

optical activity

-

technique(s)

cell culture | mammalian: suitable

technique(s)

NMR: suitable

technique(s)

ligand binding assay: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

endotoxin, tested

impurities

insoluble matter, passes filter test, ≤0.3% foreign amino acids

impurities

isoleucine and methionine, essentially free

impurities

-

color

white

color

white

color

white to off-white

color

white

General description

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.

Application

L-Leucine has been used:

  • as a hypertrophic agent to monitor its effects on myotubes.
  • as a component of PMG media for culturing yeast.
  • in myotube protein synthesis analysis in skeletal muscle cells.
  • to study its effects on hepatic lipid metabolism.

Biochem/physiol Actions

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.

Other Notes

The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

comparable product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 2

1 of 2

L-Arginine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

A8094

L-Arginine

Millipore

Millipore

1.05360

L-Leucine

Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time
Sylvia M
Bioscience Reports (2016)
(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells
Edwards S J, et al.
The Journal of Nutritional Biochemistry, 110, 109150- 109150 (2022)
Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases
David J
F1000Research (2014)
The role of leucine and its metabolites in protein and energy metabolism
Duan Y, et al.
Amino Acids, 48(1), 41-51 (2016)
Leucine in Obesity: Therapeutic Prospects
Yao K, et al.
Trends in Pharmacological Sciences, 37(8), 714-727 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service