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L9507

Sigma-Aldrich

Lactoferrin from bovine milk

≥85% (SDS-PAGE)

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Synonym(s):
Bos d LF, Lactotransferrin
CAS Number:
MDL number:
NACRES:
NA.61

biological source

bovine milk

Quality Level

assay

≥85% (SDS-PAGE)

form

powder

mol wt

~87 kDa

technique(s)

fractionation: suitable

solubility

H2O: soluble 10 mg/mL

UniProt accession no.

storage temp.

2-8°C

Gene Information

cow ... LTF(280846)

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This Item
L0520L4894L3770
Lactoferrin from bovine milk ≥85% (SDS-PAGE)

L9507

Lactoferrin from bovine milk

Lactoferrin from human milk ≥85% (SDS-PAGE), lyophilized powder

L0520

Lactoferrin from human milk

Lactoferrin from human milk powder, BioReagent, suitable for cell culture

L4894

Lactoferrin from human milk

Lactoferrin from human milk Iron saturated, ≥85% (SDS-PAGE)

L3770

Lactoferrin from human milk

technique(s)

fractionation: suitable

technique(s)

microbiological culture: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

microbiological culture: suitable

biological source

bovine milk

biological source

human milk

biological source

-

biological source

human milk

mol wt

~87 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

form

powder

form

lyophilized powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

Lactoferrin was used in the fractionation of lactoperoxidase and lactoferrin from bovine whey using a cation exchange membrane. It was used in the determination of lactoferrin and immunoglobulin G in animal milks by new immunosensors.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Mona M Abdel-Wahab et al.
Fish & shellfish immunology, 111, 160-169 (2021-02-09)
The present study was carried out to investigate the effects of dietary bovine lactoferrin (BLF) or chitosan nanoparticles (CHN) alone or in combinations on serum biochemical indices, antioxidative capacity, transcriptomic responses, non-specific immunity, and resistance of Nile tilapia (Oreochromis niloticus)
O Oyen et al.
FEBS letters, 229(2), 391-394 (1988-03-14)
Cyclic AMP (cAMP) and its action by way of cAMP-dependent protein kinase is important for sperm motility. Previous studies on germ cells have demonstrated a selective decrease in the amount of type I cAMP-dependent protein kinase during spermatid development, and
Chih-Ching Yen et al.
Molecular imaging and biology, 22(3), 526-538 (2019-07-10)
High levels of oxygen are usually used in ventilatory support and extracorporeal membrane oxygenation (ECMO) in the intensive care unit of hospitals. Hyperoxia may induce the production of reactive oxygen species (ROS) that can cause lung damage and even systemic
Fractionation of Lactoperoxidase and Lactoferrin from Bovine Whey Using a Cation Exchange Membrane
Clovis k. Chiu and Mark R.
Journal of Food Science, 62, 996-1000 (1997)
Huiying Li et al.
Foods (Basel, Switzerland), 11(24) (2022-12-24)
Although increasing evidence shows the association between type 2 diabetes (T2D) and colorectal cancer, the related mechanism remains unclear. This study examined the suppressive effect of lactoferrin (LF) on the development of T2D-induced colon cancer. First, a co-cultured cell model

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