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M0252

Sigma-Aldrich

Methylglyoxal solution

~40% in H2O

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Synonym(s):
Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde
Linear Formula:
CH3COCHO
CAS Number:
Molecular Weight:
72.06
Beilstein/REAXYS Number:
906750
MDL number:
PubChem Substance ID:
NACRES:
NA.32

form

liquid

Quality Level

concentration

~40% (enzymatic)
~40% in H2O

density

1.17 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

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This Item
67028W296902170216
Methylglyoxal solution ~40% in H2O

M0252

Methylglyoxal solution

Methylglyoxal solution technical, ~40% in H2O

67028

Methylglyoxal solution

Pyruvaldehyde solution 40 wt. % in H2O

W296902

Pyruvaldehyde solution

Methylglyoxal 1,1-dimethyl acetal ≥97%

170216

Methylglyoxal 1,1-dimethyl acetal

form

liquid

form

-

form

-

form

liquid

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

concentration

~40% (enzymatic)

concentration

~40% in H2O

concentration

40 wt. % in H2O

concentration

-

density

1.17 g/mL at 25 °C (lit.)

density

1.19 g/mL at 20 °C

density

1.178 g/mL at 25 °C

density

0.976 g/mL at 25 °C (lit.)

General description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

Application

Methylglyoxal solution has been used:
  • to assess glyoxalase 1 (GLO1) enzymatic activity
  • as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
  • to regulate anxiety like behavior in mice
  • to induce peritoneal fibrosis in rats
  • to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
  • for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Customers Also Viewed

Regular and moderate exercise counteracts the decline of antioxidant protection but not methylglyoxal-dependent glycative burden in the ovary of reproductively aging mice
Falone S, et al.
Oxidative Medicine and Cellular Longevity, 2016 (2016)
The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis
Fan YP, et al.
Stem Cells Translational Medicine, 5(2), 235-247 (2016)
Methylglyoxal requires AC1 and TRPA1 to produce pain and spinal neuron activation
Griggs RB, et al.
Frontiers in Neuroscience, 11, 679-679 (2017)
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice
McMurray KMJ, et al.
Behavioural Brain Research, 301, 119-123 (2016)
Measurement of the modification and interference rate of urinary albumin detected by size-exclusion HPLC
Marko L, et al.
Physiological Measurement, 30(10), 1137-1137 (2009)

Articles

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