M0567
Microsomes from Liver, Pooled
from human male
Synonym(s):
lab equipment accessory
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About This Item
NACRES:
NA.54
UNSPSC Code:
12352204
Biological source:
human male
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biological source
human male
form
liquid
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
Quality Level
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This Item | |||
|---|---|---|---|
| biological source human male | biological source human | biological source human female | biological source mouse (CD-1) |
| form liquid | form - | form liquid | form liquid |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| packaging vial of ~10 mg | packaging vial of ~10 mg | packaging vial of ~10 mg | packaging vial of ~10 mg |
Application
Microsomes from Liver, Pooled has been used:
- in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process[1]
- as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)[2]
- to study the metabolization of enantiomeric peptide D3[3]
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes. [6]
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ali S Abdelhameed et al.
Royal Society open science, 6(6), 190434-190434 (2019-07-18)
Spebrutinib (SBT) is a Bruton's tyrosine kinase inhibitor. SBT is currently in phase II and phase I clinical trials for the management of rheumatoid arthritis and chronic lymphocytic leukaemia, respectively. We developed and validated a liquid chromatography tandem mass spectrometry
Anne Elfgen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 107, 203-207 (2017-07-18)
The aggregation of the amyloid β protein (Aβ) plays an important role in the pathology of Alzheimer's disease. Previously, we have developed the all-d-enantiomeric peptide D3, which is able to eliminate neurotoxic Aβ oligomers in vitro and improve cognition in
Ali S Abdelhameed et al.
Drug design, development and therapy, 14, 5259-5273 (2020-12-11)
Ensartinib (ESB) is a novel anaplastic lymphoma kinase inhibitor (ALK) with additional activity against Abelson murine leukemia (ABL), met proto-oncogene (MET), receptor tyrosine kinase (AXL), and v-ros UR2 sarcoma virus oncogene homolog 1 (ROS1) and is considered a safer alternative
Sarvesh C Vashishtha et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(10), 1070-1076 (2002-09-14)
N-Glucuronidation at an aromatic tertiary amine of 5-membered polyaza ring systems was investigated for a model series of eight 1-substituted imidazoles in liver microsomes from five species. The major objectives were to investigate substrate specificities of the series in human
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
T OMURA et al.
The Journal of biological chemistry, 239, 2370-2378 (1964-07-01)
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