Medrone, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

biological source









cell analysis: suitable


chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

shipped in


storage temp.

room temp

SMILES string




InChI key


Gene Information

human ... NR3C1(2908)
rat ... Nr3c1(24413)

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6α-Methylprednisolone has been used:
  • to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
  • to induce depletion of CD14+ CD16+ monocytes
  • to study its effect on behavioral and sensory afferent hypersensitivity

Biochem/physiol Actions

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.


Bottomless glass bottle. Contents are inside inserted fused cone.


Health hazard

Signal Word


Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What solvents can be used for Methylprednisolone?

    Sigma tests the solublity of Methylprednisolone at 50 mg/ml in chloroform:methanol (1:1) yielding a clear, colorless to faint yellow solution. This product is practically insoluble in water, soluble 1 in 100 of dehydrated ethanol (10 mg/ml), slightly soluble in chloroform and ether; sparingly soluble in dioxan and methanol.  It has been reported that this product is soluble in DMSO at a concentration of 100 mM. An NMR has been run using DMSO-d6 suggesting this product is soluble at 5-10 mg/ml in DMSO.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

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Mechanism of glucocorticoid-induced depletion of human CD14+ CD16+ monocytes
Dayyani F, et al.
Journal of Leukocyte Biology, 74(1), 33-39 (2003)
Ling Ye et al.
Anesthesiology, 121(3), 632-643 (2014-05-02)
Localized inflammation of lumbar dorsal root ganglia (DRG) may contribute to low back pain. Local injections of corticosteroids used for low back pain are sometimes ineffective. Many corticosteroids activate not only the target glucocorticoid receptor (GR) but also the mineralocorticoid...
Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene
Unterberger C, et al.
Molecular Immunology, 45(11), 3230-3237 (2008)
Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats
Ye L, et al.
Anesthesiology, 121(3), 632-643 (2014)
Formulation development and evaluation of Methylprednisolone dispersible tablets
Nandhini J and Rajalakshmi AN
Asian Journal of Pharmacy and Pharmacology, 4(4), 514-521 (2018)

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