Documents
M0639
6α-Methylprednisolone
≥98%
Quality Level
biological source
synthetic
sterility
non-sterile
assay
≥98%
form
powder
application(s)
cell analysis: suitable
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChI key
VHRSUDSXCMQTMA-PJHHCJLFSA-N
Gene Information
human ... NR3C1(2908)
rat ... Nr3c1(24413)
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Application
- to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
- to induce depletion of CD14+ CD16+ monocytes
- to study its effect on behavioral and sensory afferent hypersensitivity
Biochem/physiol Actions
Packaging
Signal Word
Danger
Hazard Statements
Precautionary Statements
Personal Protective Equipment
RIDADR
NONH for all modes of transport
WGK Germany
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What solvents can be used for Methylprednisolone?
Sigma tests the solublity of Methylprednisolone at 50 mg/ml in chloroform:methanol (1:1) yielding a clear, colorless to faint yellow solution. This product is practically insoluble in water, soluble 1 in 100 of dehydrated ethanol (10 mg/ml), slightly soluble in chloroform and ether; sparingly soluble in dioxan and methanol. It has been reported that this product is soluble in DMSO at a concentration of 100 mM. An NMR has been run using DMSO-d6 suggesting this product is soluble at 5-10 mg/ml in DMSO.
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