M0639

6α-Methylprednisolone

≥98%

• Synonym(s): 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, Medrone
• Empirical Formula (Hill Notation): C₂₂H₃₀O₅
• CAS Number: 83-43-2
• Molecular Weight: 374.47
• Beilstein: 2340300
• EC Number: 201-476-4
• MDL number: MFCD00010591
• PubChem Substance ID: 24896564
• NACRES: NA.77

Properties

• biological source: synthetic
• Quality Level: 200
• sterility: non-sterile
• assay: ≥98%
• form: powder
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• application(s): cell analysis
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
• InChI key: VHRSUDSXCMQTMA-PJHHCJLFSA-N
• Gene Information: human ... NR3C1(2908) ; rat ... Nr3c1(24413)

Description

Application

6α-Methylprednisolone has been used:

• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene[1]
• to induce depletion of CD14⁺ CD16⁺ monocytes[2]
• to study its effect on behavioral and sensory afferent hypersensitivity[3]

Biochem/physiol Actions

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions.[4] It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.[5]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360FD - H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves