M0689

Myelin Basic Protein Antigen from human brain

≥95% (SDS-PAGE)

• MDL number: MFCD03457654
• NACRES: NA.32

Properties

• biological source: human brain
• Quality Level: 200
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• technique(s): ELISA: suitable
• UniProt accession no.: P02686
• storage temp.: −20°C
• Gene Information: human ... MBP(4155)

Description

General description

Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).

Application

Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.

Biochem/physiol Actions

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.

Determined using polyclonal and monoclonal antibodies against MBP.

Physical form

Lyophilized from 10mM HCl.

Other Notes

Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves