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M0939

Sigma-Aldrich

Anti-α-MSH antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Synonym(s):
Anti-α-Melanocyte Stimulating Hormone
MDL number:
NACRES:
NA.46

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 1664.9 kDa

species reactivity

human

technique(s)

ELISA: 1:4,000
microarray: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... POMC(5443)

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biological source

rabbit

biological source

goat

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

IgG fraction of antiserum

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

technique(s)

ELISA: 1:4,000, microarray: suitable

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

technique(s)

western blot: 1 μg/mL

technique(s)

indirect immunofluorescence: suitable, western blot: 1:500-1:2,000

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General description

Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.

Immunogen

synthetic α-MSH peptide conjugated to bovine serum albumin.

Application

Anti-α-MSH antibody produced in rabbit has been used in:
  • immunohistochemistry
  • radioimmunoassay/α-MSH immunoassay
  • enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.
α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
Siu JJ, et al.
Molecular therapy. Methods & clinical development, 7, 83-95 (2017)
N Rajora et al.
Journal of leukocyte biology, 59(2), 248-253 (1996-02-01)
alpha-Melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide derived from pro-opiomelanocortin, has potent antiinflammatory activity in laboratory animals. alpha-MSH inhibits nitric oxide production by murine macrophages, an influence believed to reflect activation of an autocrine circuit in these cells, one that is based
Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
Stout GJ and Blasco MA
Disease models & mechanisms, 2(3-4), 139-156 (2009)
alpha-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
Enriori PJ, et al.
Molecular Metabolism, 5(10), 807-822 (2016)
G Hunt et al.
Journal of cell science, 107 ( Pt 1), 205-211 (1994-01-01)
Although melanocyte stimulating hormone (MSH) peptides are known to stimulate pigmentation in man, previous reports suggest that human melanocytes are relatively unresponsive to these peptides in vitro. This may be related to the conditions under which the melanocytes were cultured.

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