M110

α-Methylserotonin maleate salt

Name: α-Methylserotonin maleate salt
Brand: SIGMA
Price: 106 USD
Availability: InStock

≥98% (HPLC)

Synonym(s):

α-Methyl-5-hydroxytryptamine maleate salt, (±)-3-(2-Aminopropyl)indol-5-ol maleate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₄N₂O · C₄H₄O₄

CAS Number:

97469-12-0

Molecular Weight:

306.31

MDL number:

MFCD00082468

UNSPSC Code:

12352200

PubChem Substance ID:

24278102

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to dark brown

solubility

H₂O: >3 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(N)Cc1c[nH]c2ccc(O)cc12

InChI

1S/C11H14N2O.C4H4O4/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11;5-3(6)1-2-4(7)8/h2-3,5-7,13-14H,4,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

YQNHFSXRABPJLP-BTJKTKAUSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

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Show Differences

1 of 4

This Item	SML0640	A7111	SML1504
Sigma-Aldrich M110 α-Methylserotonin maleate salt	Sigma-Aldrich SML0640 2-Methylserotonin maleate	Sigma-Aldrich A7111 Acepromazine maleate	Sigma-Aldrich SML1504 Tegaserod maleate
assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. room temp	storage temp. 2-8°C
solubility H₂O: >3 mg/mL, clear (warmed)	solubility H₂O: 5 mg/mL, clear	solubility H₂O: >10 mg/mL	solubility DMSO: 20 mg/mL, clear
color white to beige	color white to brown	color yellow	color white to beige

Biochem/physiol Actions

5-HT₂ serotonin receptor agonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effects of serotonin-1 and serotonin-2 receptor agonists on neuronal activity in the nucleus tractus solitarius.

P D Feldman

Journal of the autonomic nervous system, 56(1-2), 119-124 (1995-12-05)

Spontaneous neuronal activity in the solitary tract nucleus was recorded extracellularly in a brain slice preparation during bath-application of 5-HT1 and 5-HT2 receptor-selective agonists and antagonists. The 5-HT1A/5-HT1B agonist 5-carboxamidotryptamine depressed activity in 20 of 25 neurons studied. The remaining

5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin.

A M Ismaiel et al.

Journal of medicinal chemistry, 33(2), 755-758 (1990-02-01)

alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT; 2) and 2-methyl-5-hydroxytryptamine (2-Me-5-HT; 3) are considered to be 5-HT2-selective and 5-HT3-selective agents, respectively. These agents were synthesized and examined at serotonin (5-HT) binding sites because there is relatively little documentation as to their selectivity and because they

Leflunomide Synergizes with Gemcitabine in Growth Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting.

Ralf Buettner et al.

Molecular therapy oncolytics, 14, 149-158 (2019-06-19)

The immunosuppressive agent leflunomide has been used in the treatment of over 300,000 patients with rheumatoid arthritis. Its active metabolite, teriflunomide (Ter), directly inhibits dihydroorotate dehydrogenase (DHODH), an enzyme involved in nucleoside synthesis. We report that Ter not only shows

Serotonin via 5-HT1B and 5-HT2B receptors stimulates anion secretion in the rat epididymal epithelium.

G P Leung et al.

The Journal of physiology, 519 Pt 3, 657-667 (1999-08-24)

1. The short-circuit current (Isc) technique was used to study the role of 5-hydroxytryptamine (5-HT) in the regulation of anion secretion in cultured rat cauda epididymal epithelia. 2. 5-HT, the 5-HT1B-selective agonist 5-nonyloxytryptamine (5-NOT) and the 5-HT2B-selective agonist alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT)

Viral rhodopsins 1 are an unique family of light-gated cation channels.

Dmitrii Zabelskii et al.

Nature communications, 11(1), 5707-5707 (2020-11-13)

Phytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and regulate the phytoplankton dynamics encompass

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α-Methylserotonin maleate salt