M1195

Metolazone

Name: Metolazone
Brand: SIGMA
Price: 180 USD

≥98% (HPLC), solid

Synonym(s):

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆ClN₃O₃S

CAS Number:

17560-51-9

Molecular Weight:

365.83

EC Number:

241-539-3

MDL number:

MFCD00069304

UNSPSC Code:

12352200

PubChem Substance ID:

24724532

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >5 mg/mL

SMILES string

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

InChI key

AQCHWTWZEMGIFD-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557), SLC12A3(6559)

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Bioactive Small Molecule Inhibitors

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Show Differences

1 of 4

This Item	M8515	SML1781	SML0481
Sigma-Aldrich M1195 Metolazone	Sigma-Aldrich M8515 Monastrol	Sigma-Aldrich SML1781 PDD00017273	Sigma-Aldrich SML0481 Qc1
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: >5 mg/mL	solubility DMSO: >5 mg/mL	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 5 mg/mL (clear solution, warmed)
color white	color white to off-white	color white to beige	color white to beige
Gene Information human ... SLC12A1(6557), SLC12A3(6559)	Gene Information -	Gene Information -	Gene Information -

Biochem/physiol Actions

Inhibitor of thiazide-sensitive Na⁺-Cl^- cotransporter; antihypertensive; moderate "loop" diuretic.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000496627

0000438056

0000438055

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Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.

Jens Rosenberg et al.

Cardiovascular drugs and therapy, 19(4), 301-306 (2005-09-29)

Metolazone is a potent thiazide-like diuretic. It is recommended in severe congestive heart failure (HF). We conducted a review of the existing literature and found that the available information on the use of metolazone in HF is based on studies

Difficulties of introducing the National Service Framework for heart failure into general practice in the UK.

Nigel Sparrow et al.

European journal of heart failure, 5(3), 355-361 (2003-06-12)

The National Service Framework (NSF) sets standards for the management of heart failure in the UK. Loop diuretics are commonly first prescribed in primary care. Some patients taking these drugs have heart failure and may benefit from other treatments including

How much responsibility should heart failure nurses take?

Lynda Blue et al.

European journal of heart failure, 7(3), 351-361 (2005-02-19)

This article examines the emerging role of the heart failure nurse and the responsibilities and educational and training requirements surrounding such a role. There may be variations in the role and its responsibilities in different health care settings. However the

Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.

A Monroy et al.

American journal of physiology. Renal physiology, 279(1), F161-F169 (2000-07-15)

The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is the major pathway for salt reabsorption in the apical membrane of the mammalian distal convoluted tubule. When expressed in Xenopus laevis oocytes, rat TSC exhibits high affinity for both cotransported ions, with the Michaelis-Menten

[Therapy edema: secondary effect without effect!].

B Truniger

Schweizerische medizinische Wochenschrift, 129(46), 1808-1808 (1999-12-22)

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Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

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Metolazone