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M1195

Sigma-Aldrich

Metolazone

≥98% (HPLC), solid

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Synonym(s):
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Empirical Formula (Hill Notation):
C16H16ClN3O3S
CAS Number:
Molecular Weight:
365.83
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >5 mg/mL

SMILES string

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

InChI key

AQCHWTWZEMGIFD-UHFFFAOYSA-N

Gene Information

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1 of 4

This Item
Y0000701Y0000702M8515
vibrant-m

M1195

Metolazone

vibrant-m

Y0000701

Metolazone

vibrant-m

M8515

Monastrol

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

solid

form

-

form

-

form

solid

color

white

color

-

color

-

color

white to off-white

solubility

DMSO: >5 mg/mL

solubility

-

solubility

-

solubility

DMSO: >5 mg/mL

Gene Information

human ... SLC12A1(6557), SLC12A3(6559)

Gene Information

human ... SLC12A3(6559)

Gene Information

human ... SLC12A3(6559)

Gene Information

-

Biochem/physiol Actions

Inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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[Therapy edema: secondary effect without effect!].
B Truniger
Schweizerische medizinische Wochenschrift, 129(46), 1808-1808 (1999-12-22)
S C Hebert et al.
Kidney international, 49(6), 1638-1641 (1996-06-01)
Recently the molecular identification of the major electroneutral sodium-potassium-chloride entry mechanisms present on apical membranes of distal nephron segments of the mammalian kidney, on basolateral membranes of many non-renal epithelial cells and on certain non-epithelial tissues has been achieved. These
Lynda Blue et al.
European journal of heart failure, 7(3), 351-361 (2005-02-19)
This article examines the emerging role of the heart failure nurse and the responsibilities and educational and training requirements surrounding such a role. There may be variations in the role and its responsibilities in different health care settings. However the
Jens Rosenberg et al.
Cardiovascular drugs and therapy, 19(4), 301-306 (2005-09-29)
Metolazone is a potent thiazide-like diuretic. It is recommended in severe congestive heart failure (HF). We conducted a review of the existing literature and found that the available information on the use of metolazone in HF is based on studies
Nigel Sparrow et al.
European journal of heart failure, 5(3), 355-361 (2003-06-12)
The National Service Framework (NSF) sets standards for the management of heart failure in the UK. Loop diuretics are commonly first prescribed in primary care. Some patients taking these drugs have heart failure and may benefit from other treatments including

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Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

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