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MilliporeSigma

M1198

Sigma-Aldrich

MEK2, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

MAP2K2, MAPKK2, MKK2, PRKMK2

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$456.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

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$456.00

-15% with code SMR15
Web-Only Discount
Check Cart for Availability
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

190-258 nmol/min·mg

mol wt

~71 kDa

UniProt accession no.

P36507

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAP2K2(5605)

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MEK2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

M1198

MEK2, active, GST tagged human

MEKK2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

M0324

MEKK2, active, GST tagged human

MEKK3, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

M0449

MEKK3, active, GST tagged human

MEK1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

M8822

MEK1, active, GST tagged human

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

Gene Information

human ... MAP2K2(5605)

Gene Information

human ... MAP3K2(10746)

Gene Information

human ... MAP3K3(4215)

Gene Information

human ... Map2k1(26395)

specific activity

190-258 nmol/min·mg

specific activity

192-260 nmol/min·mg

specific activity

17-23 nmol/min·mg

specific activity

276-374 nmol/min·mg

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

UniProt accession no.

P36507

UniProt accession no.

Q9Y2U5

UniProt accession no.

Q99759

UniProt accession no.

P31938

Biochem/physiol Actions

MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways. Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN1818V
SLBC3614V

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