M1318

Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride, F 2207, Midalcipran, Toledomin

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₂N₂O · HCl

CAS Number:

101152-94-7

Molecular Weight:

282.81

NACRES:

NA.77

PubChem Substance ID:

329817868

UNSPSC Code:

12352200

MDL number:

MFCD00901293

Key Documents

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InChI

1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

SMILES string

Cl[H].CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

InChI key

XNCDYJFPRPDERF-PBCQUBLHSA-N

description

Relative stereochemistry, Store with desiccants

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: 19 mg/mL

originator

Cypress Bioscience

storage temp.

2-8°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

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Show Differences

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This Item	A7606	C0742	SML0893
Sigma-Aldrich M1318 Milnacipran hydrochloride	Sigma-Aldrich A7606 Aprindine hydrochloride	Sigma-Aldrich C0742 CKI-7 dihydrochloride	Sigma-Aldrich SML0893 M8-B hydrochloride
form solid	form solid	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility H₂O: 19 mg/mL	solubility H₂O: >10 mg/mL	solubility H₂O: >5 mg/mL	solubility H₂O: 2 mg/mL, clear (warmed)
color white	color -	color white to light tan	color white to beige

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

Features and Benefits

This compound was developed by Cypress Bioscience. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Pharmacological effects of milnacipran, a new antidepressant, given repeatedly on the alpha1-adrenergic and serotonergic 5-HT2A systems.

J Maj et al.

Journal of neural transmission (Vienna, Austria : 1996), 107(11), 1345-1359 (2001-01-06)

Milanacipran (MIL) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the reuptake of serotonin and noradrenaline but, in contrast to tricyclics, show no affinity for neurotransmitter receptors. The present study was aimed at determining whether

Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats.

Hiroshi Kawai et al.

Biological & pharmaceutical bulletin, 41(2), 213-219 (2018-02-02)

Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran

Inhibitory Effects of Antidepressants on Acetylcholine-Induced Contractions in Isolated Guinea Pig Urinary Bladder Smooth Muscle.

Junji Uno et al.

Pharmacology, 99(1-2), 89-98 (2016-10-25)

To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. Concentration-response curves for ACh-induced contractions in guinea

No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test battery.

P Okkerse et al.

European journal of pain (London, England), 21(3), 494-506 (2016-09-22)

Serotonin-norepinephrine reuptake inhibitors inhibit the reuptake of serotonin and noradrenalin and are used in the treatment of neuropathic pain. Animal studies suggest that milnacipran co-administered with opioids may potentiate the analgesic effect of μ-opioid receptor agonists. This study hypothesized that

Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus.

Tsugunobu Andoh et al.

Biological & pharmaceutical bulletin, 43(7), 1111-1117 (2020-07-03)

Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition

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