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M149

Sigma-Aldrich

Methiothepin mesylate salt

≥98% (HPLC), solid

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Synonym(s):
1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt
Linear Formula:
C20H24N2S2 · CH3SO3H
CAS Number:
Molecular Weight:
452.65
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: 13 mg/mL

SMILES string

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChI key

CZMDZGZYKOGLJY-UHFFFAOYSA-N

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This Item
O111I3639D9533
Methiothepin mesylate salt ≥98% (HPLC), solid

M149

Methiothepin mesylate salt

Octoclothepin maleate salt solid

O111

Octoclothepin maleate salt

Isoetharine mesylate salt

I3639

Isoetharine mesylate salt

Deferoxamine mesylate salt ≥92.5% (TLC), powder

D9533

Deferoxamine mesylate salt

form

solid

form

solid

form

-

form

powder

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: 13 mg/mL

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >21 mg/mL

solubility

-

solubility

H2O: 50 mg/mL

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white

color

white

color

-

color

white to off-white

General description

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

Application

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

Biochem/physiol Actions

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Yuan Lai et al.
Neurobiology of learning and memory, 173, 107278-107278 (2020-07-12)
Conditioned taste aversion (CTA) learning induces the devaluation of a preferred food through its pairing with a stimulus inducing internal illness. In invertebrates, it is still unclear how this aversive learning impairs the memories of stimuli that had been associated
P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
Blockade of central 5-hydroxytryptamine receptors by methiothepin
Monachon M A, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 274(2), 192-197 (1972)
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)
D J McLoughlin et al.
Journal of neurochemistry, 74(1), 347-357 (2000-01-05)
Mechanisms of agonist and inverse agonist action at the serotonin 5-HT1A receptor have been studied using the modulation of guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) binding in membranes of Chinese hamster ovary (CHO) cells expressing the receptor (CHO-5-HTA1A cells). A range of agonists

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