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M1508

Sigma-Aldrich

4-Methylumbelliferone sodium salt

≥98% (HPLC), crystalline

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Synonym(s):
β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
Linear Formula:
C10H7O3Na
CAS Number:
Molecular Weight:
198.15
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Assay

≥98% (HPLC)

form

crystalline

color

yellow

solubility

water: 50 mg/mL

SMILES string

[Na+].CC1=CC(=O)Oc2cc([O-])ccc12

InChI

1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1

InChI key

JGMQHDNPUCPRQE-UHFFFAOYSA-M

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This Item
M1381M3885N1628
4-Methylumbelliferone ≥98%

Sigma-Aldrich

M1381

4-Methylumbelliferone

MES sodium salt ≥99% (titration)

Sigma-Aldrich

M3885

MES sodium salt

Novobiocin sodium salt ≥90% (HPLC)

Sigma-Aldrich

N1628

Novobiocin sodium salt

form

crystalline

form

-

form

crystalline powder

form

powder

color

yellow

color

off-white to yellow

color

-

color

white to yellow

solubility

water: 50 mg/mL

solubility

-

solubility

water: 0.5 g/mL, clear, colorless

solubility

-

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

200

General description

4-methylumbelliferone (4-MU) is a coumarin derivative.

Application

4-Methylumbelliferone sodium salt has been used:
  • as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
  • as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
  • in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer

Biochem/physiol Actions

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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