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M1544

Resorufin methyl ether

Synonym(s):

7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O7-Methylresorufin

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$235.00

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About This Item

Empirical Formula (Hill Notation):
C13H9NO3
CAS Number:
5725-89-3
Molecular Weight:
227.22
UNSPSC Code:
12161501
NACRES:
NA.47
PubChem Substance ID:
24896665
MDL number:
MFCD00037663
Beilstein/REAXYS Number:
209529

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InChI

1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3

SMILES string

COc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI key

KNYYMGDYROYBRE-UHFFFAOYSA-N

assay

≥98.0% (HPLC)

form

powder

mp

≥220 °C (lit.)

solubility

dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange

storage temp.

2-8°C

Quality Level

200

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1 of 4

This Item
B153246121E3763
Resorufin methyl ether

Sigma-Aldrich

M1544

Resorufin methyl ether

Resorufin benzyl ether CYP450 substrate

Sigma-Aldrich

B1532

Resorufin benzyl ether

Resorufin ethyl ether suitable for fluorescence, ≥95% (UV)

Sigma-Aldrich

46121

Resorufin ethyl ether

Resorufin ethyl ether ≥98% (TLC), powder

Sigma-Aldrich

E3763

Resorufin ethyl ether

assay

≥98.0% (HPLC)

assay

≥98% (TLC)

assay

≥95% (UV)

assay

≥98% (TLC)

solubility

dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

solubility

DMF: soluble, DMSO: soluble, alcohols: soluble

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

form

powder

form

powder

form

solid

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

mp

≥220 °C (lit.)

mp

-

mp

223-225 °C (lit.)

mp

223-225 °C (lit.)

Application

Resorufin methyl ether have been used as substrate in the incubation mixture, during the determination of cytochrome P4501A activities such as ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase(MROD) in liver microsomes, using high performance liquid chromatography(HPLC).[1]

Biochem/physiol Actions

Fluorimetric substrate for cytochrome P450 linked enzymes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
124M4041V
018M4075V
068M4091V
13140615
0000111536

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Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.
McCart C and ffrench-Constant R H
Pest Management Science, 64(6), 639-645 (2008)
Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection
Hanioka N, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 744(2), 399-406 (2000)
Caroline McCart et al.
Pest management science, 64(6), 639-645 (2008-03-14)
The cytochrome P450 gene Cyp6g1 is overtranscribed in all field isolates of DDT-resistant Drosophila melanogaster (Meigen) and confers a fitness advantage when inherited via the female. Overtranscription is associated with the insertion of an Accord transposable element into the 5'
Xiaowei Zhang et al.
Toxicology and applied pharmacology, 234(3), 306-313 (2008-12-02)
As part of an ongoing effort to understand aryl hydrocarbon receptor (AhR) mediated toxicity in mink, cDNAs encoding for CYP1A1 and the CYP1A2 mixed function monooxygenases were cloned and characterized. In addition, the effects of selected dibenzofurans on the expression
Nicholas E Hadjokas et al.
British journal of pharmacology, 136(3), 347-352 (2002-05-25)
1. Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity. Molecular
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Phase I Drug Metabolism

Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.

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