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M1787

Sigma-Aldrich

Manganese(II) chloride solution

BioReagent, for molecular biology, storage temp.: room temp

Linear Formula:
MnCl2
CAS Number:
Molecular Weight:
125.84
MDL number:
PubChem Substance ID:
NACRES:
NA.52

Quality Level

grade

for molecular biology

sterility

0.2 μm filtered

product line

BioReagent

form

liquid

concentration

1.00 M±0.01 M

cation traces

heavy metals (as Pb): ≤5 ppm

foreign activity

DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected

storage temp.

room temp

SMILES string

Cl[Mn]Cl

InChI

1S/2ClH.Mn/h2*1H;/q;;+2/p-2

InChI key

GLFNIEUTAYBVOC-UHFFFAOYSA-L

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General description

Manganese (II) chloride (MnCl2) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl2 has been used in reverse transcription reaction mix to enhance the template-switching efficiency.
MnCl2 solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn2+ can be substituted for Mg2+ as a divalent metal ion to facilitate DNase I activity in presence of Ca2+.

Application

Manganese (II) chloride solution has been used:
  • in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
  • in high ionic strength reaction mixture to determine RNA polymerase I and II activity
  • in reverse transcription reaction mix as a source of Mn2+ ions

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - STOT RE 2

Target Organs

Brain

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

More Documents

Quotes and Ordering

In vitro Assessment of RNA Polymerase I Activity
Govoni M
Oncogene (2016)
Highly multiplexed and strand-specific single-cell RNA 5′ end sequencing
Islam S, et al.
Nature Protocols, 7(5), 813-813 (2012)
Molecular Cloning: A Laboratory Manual
Sambrook, J. and Russel, D.W.
Molecular Cloning: A Laboratory Manual, 1, A4-A4 (2001)
Syndecan-1 regulates cell migration and fibronectin fibril assembly
Stepp MA, et al.
Experimental Cell Research, 316(14), 2322-2339 (2010)
Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe
Daoust A, et al.
Neuroimage, 64, 10-18 (2013)

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