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M1787

Sigma-Aldrich

Manganese(II) chloride solution

BioReagent, for molecular biology, storage temp.:room temp

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Synonym(s):
Manganese chlroide, Manganese(II) chloride, MnCl2
Linear Formula:
MnCl2
CAS Number:
Molecular Weight:
125.84
MDL number:
PubChem Substance ID:
NACRES:
NA.52

grade

for molecular biology

Quality Level

sterility

0.2 μm filtered

product line

BioReagent

form

liquid

concentration

1.00 M±0.01 M

cation traces

heavy metals (as Pb): ≤5 ppm

foreign activity

DNase, Exonuclease; NICKase, Endonuclease; and protease, none detected

storage temp.

room temp

SMILES string

Cl[Mn]Cl

InChI

1S/2ClH.Mn/h2*1H;/q;;+2/p-2

InChI key

GLFNIEUTAYBVOC-UHFFFAOYSA-L

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1 of 4

This Item
244589M102863535
vibrant-m

M1787

Manganese(II) chloride solution

Essential+ Grade
vibrant-m

244589

Manganese(II) chloride

-
vibrant-m

M1028

Magnesium chloride solution

-
vibrant-m

63535

Manganese(II) chloride tetrahydrate

Premium Grade
form

liquid

form

powder and chunks

form

liquid

form

-

cation traces

heavy metals (as Pb): ≤5 ppm

cation traces

-

cation traces

heavy metals (as Pb): ≤5 ppm

cation traces

-

grade

for molecular biology

grade

-

grade

for molecular biology

grade

for molecular biology

sterility

0.2 μm filtered

sterility

-

sterility

non-sterile; 0.2 μm filtered

sterility

-

product line

BioReagent

product line

-

product line

-

product line

BioUltra

General description

Manganese (II) chloride (MnCl2) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism. MnCl2 has been used in reverse transcription reaction mix to enhance the template-switching efficiency.
MnCl2 solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn2+ can be substituted for Mg2+ as a divalent metal ion to facilitate DNase I activity in presence of Ca2+.

Application

Manganese (II) chloride solution has been used:
  • in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicity
  • in high ionic strength reaction mixture to determine RNA polymerase I and II activity
  • in reverse transcription reaction mix as a source of Mn2+ ions

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2

target_organs

Brain

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)


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Molecular Cloning: A Laboratory Manual
Sambrook, J. and Russel, D.W.
Molecular Cloning: A Laboratory Manual, 1, A4-A4 (2001)
Syndecan-1 regulates cell migration and fibronectin fibril assembly
Stepp MA, et al.
Experimental Cell Research, 316(14), 2322-2339 (2010)
In vitro Assessment of RNA Polymerase I Activity
Govoni M
Oncogene (2016)
Highly multiplexed and strand-specific single-cell RNA 5′ end sequencing
Islam S, et al.
Nature Protocols, 7(5), 813-813 (2012)
Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe
Daoust A, et al.
Neuroimage, 64, 10-18 (2013)

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