M2525

Mianserin hydrochloride

• Synonym(s): 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
• Empirical Formula (Hill Notation): C₁₈H₂₀N₂ · HCl
• CAS Number: 21535-47-7
• Molecular Weight: 300.83
• EC Number: 244-426-7
• MDL number: MFCD00055072
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278125
• NACRES: NA.77

Properties

• solubility: H₂O: 3.4 mg/mL; ethanol: 5.6 mg/mL
• originator: Organon
• storage temp.: 2-8°C
• SMILES string: Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24
• InChI: 1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
• InChI key: YNPFMWCWRVTGKJ-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Application

Mianserin hydrochloride has been used:

• as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)[1]
• as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression[2]
• as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation[3]

Biochem/physiol Actions

Antidepressant; antagonist/inverse agonist at 5-HT₂ serotonin receptors; also blocks the H₁ histamine receptor and the α₂ adrenoceptor.

Mianserin is a tetracyclic compound with sedative property.[4] It lacks anticholinergic activity and is not effective on serotoninergic mechanisms.[4] Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.[4]

Features and Benefits

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Solutions may be stored for several days at 4°C.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves