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M2892

Sigma-Aldrich

Methylphenidate hydrochloride

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Synonym(s):
threo-Methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride, Ritalin hydrochloride
Empirical Formula (Hill Notation):
C14H19NO2 · HCl
CAS Number:
Molecular Weight:
269.77
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

application(s)

forensics and toxicology

originator

Johnson & Johnson

SMILES string

Cl[H].COC(=O)C(C1CCCCN1)c2ccccc2

InChI

1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H

InChI key

JUMYIBMBTDDLNG-UHFFFAOYSA-N

Gene Information

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This Item
M3142M1796M8750
Methylphenidate hydrochloride

M2892

Methylphenidate hydrochloride

Meperidine hydrochloride

M3142

Meperidine hydrochloride

(+)-Methamphetamine hydrochloride

M8750

(+)-Methamphetamine hydrochloride

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

originator

Johnson & Johnson

originator

Sanofi Aventis

originator

-

originator

Teva

application(s)

forensics and toxicology

application(s)

-

application(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Gene Information

human ... SLC6A2(6530), SLC6A3(6531)

Gene Information

human ... OPRM1(4988)

Gene Information

-

Gene Information

human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Biochem/physiol Actions

CNS stimulant; releases catecholamines; potent inhibitor of dopamine reuptake

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation markHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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R Kuczenski et al.
The Journal of pharmacology and experimental therapeutics, 296(3), 876-883 (2001-02-22)
The prescribed use of methylphenidate (Ritalin) in the treatment of attention deficit hyperactivity disorder has risen dramatically in recent years. The relative roles of dopamine, norepinephrine, and serotonin in the therapeutic action of these drugs was assessed by comparing the
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), 2421-2427 (2013-05-22)
Cancer-related-fatigue (CRF) is common in advanced cancer. The primary objective of the study was to compare the effects of methylphenidate (MP) with those of placebo (PL) on CRF as measured using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) fatigue
Deirdre M McCarthy et al.
Scientific reports, 10(1), 11974-11974 (2020-07-21)
The use of non-nutritive sweeteners such as saccharin is widely prevalent. Although saccharin is considered safe for human consumption, it produces behavioral changes in experimental animals. We report that saccharin's behavioral effects are much more pervasive than currently recognized. In
Yvonne Groen et al.
PloS one, 8(3), e59240-e59240 (2013-04-05)
Current models of ADHD suggest abnormal reward and punishment sensitivity, but the exact mechanisms are unclear. This study aims to investigate effects of continuous reward and punishment on the processing of performance feedback in children with ADHD and the modulating

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