M2910

Sigma-Aldrich

[D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11

≥97% (HPLC)

Synonym(s):
GHRP-6
Empirical Formula (Hill Notation):
C46H56N12O6
CAS Number:
Molecular Weight:
873.01
MDL number:
PubChem Substance ID:

Quality Level

assay

≥97% (HPLC)

UniProt accession no.

storage temp.

−20°C

SMILES string

C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@H](Cc6ccccc6)C(=O)N[C@@H](CCCCN)C(N)=O

InChI

1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1

InChI key

WZHKXNSOCOQYQX-FUAFALNISA-N

Gene Information

human ... POMC(5443)
rat ... Ghsr(84022)

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Amino Acid Sequence

His-Trp-Ala-Trp-Phe-Lys-NH2

Biochem/physiol Actions

Selective inhibitor of α-MSH activity in frog skin bioassay; identical to (His1,Lys8)-GH which selectively releases growth hormone in vitro and in vivo; somatostatin antagonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Magdalena Arasimowicz-Jelonek et al.
Plant physiology and biochemistry : PPB, 63, 177-184 (2012-12-26)
Homocysteine (Hcy) is a naturally occurring intermediate metabolite formed during methionine metabolism. It has been well documented that its excess can be extremely toxic to mammalian, yeast and bacterial cells. In spite of the metabolic value of Hcy known for...
Diana García Del Barco-Herrera et al.
Restorative neurology and neuroscience, 31(2), 213-223 (2013-01-15)
Stroke is the second cause of mortality worldwide, with a high incidence of disability in survivors. Promising candidate drugs have failed in stroke trials. Combined therapies are attractive strategies that simultaneously target different points of stroke pathophysiology. The aim of...
Fernando Guerrero et al.
PloS one, 7(11), e50470-e50470 (2012-11-28)
The ethylene-forming enzyme (EFE) from Pseudomonas syringae catalyzes the synthesis of ethylene which can be easily detected in the headspace of closed cultures. A synthetic codon-optimized gene encoding N-terminal His-tagged EFE (EFEh) was expressed in Synechocystis sp. PCC 6803 (Synechocystis)...
Alessia Indrieri et al.
EMBO molecular medicine, 5(2), 280-293 (2012-12-15)
Mitochondrial-dependent (intrinsic) programmed cell death (PCD) is an essential homoeostatic mechanism that selects bioenergetically proficient cells suitable for tissue/organ development. However, the link between mitochondrial dysfunction, intrinsic apoptosis and developmental anomalies has not been demonstrated to date. Now we provide...
Mi-Sun Kim et al.
Bioscience, biotechnology, and biochemistry, 76(12), 2354-2356 (2012-12-12)
This study established a new system for potato transformation using toxoflavin as selection agent and toxoflavin lyase (tflA) as selectable marker gene. Potato plants expressing tflA was successfully transformed on toxoflavin medium with 27% efficiency, similar to that for the...

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