MES sodium salt

BioPerformance Certified, suitable for cell culture

4-Morpholineethanesulfonic acid sodium salt, 2-(N-Morpholino)ethanesulfonic acid sodium salt
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:


BioPerformance Certified
for molecular biology

Quality Level


cell culture | mammalian: suitable


endotoxin and total aerobic microbial count, tested

useful pH range

5.5 - 6.7



Featured Industry

Diagnostic Assay Manufacturing

foreign activity

DNase, NICKase, RNase, protease, none detected

SMILES string




InChI key


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General description

MES is one of the so-called "Good" buffers developed for biological applications. This product is BioPerformance certified (suitable for electrophoresis, tissue culture, and molecular biology applications. A buffer using MES free acid can be prepared by titrating the free acid with sodium hydroxide to the desired pH (pKa=±1). Alternatively, volumes of equimolar solutions of MES free acid and MES sodium can be mixed to attain the desired pH. Standard mixing tables using stock solutions to prepare a buffer of a given pH have been published.


MES sodium salt has been used as a coupling buffer during the coupling of MAbs onto amine-reactive sensors. It has also been used as a component of germination medium and shoot induction medium during in vitro plant regeneration.


25, 100, 500 g in poly bottle
1 kg in poly bottle

Preparation Note

MES Sodium is soluble in water, giving a clear colourless solution at 25g in 50mL water (approximately 2.3M). The pH of a solution should be between 9 and 10 depending on concentration. Solutions are stable at 2-8°C for months. Sterilization should be done by filteration through 0.2μm filters. Autoclaving is not recommended. If buffers must be nuclease-free, it is best to treat the water first, and then add the buffer solids after autoclaving. When MES solutions are autoclaved, they turn yellow (although pH does not change measurably). The identity of the yellow breakdown product is unknown.

Other Notes

Easily compare specifications for MES sodium salt products with the MES sodium salt specification table.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

In vitro plant regeneration from commercial cultivars of soybean.
Raza, G
Biomedical Research, 2017 (2017)
High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity.
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Tsuyoshi Shirai et al.
Journal of molecular biology, 321(5), 879-889 (2002-09-11)
The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin...

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