M3445

Magnolol

≥90% (HPLC), from plant

• Synonym(s): 2,2′-Bichavicol, 5,5′-Diallyl-2,2′-biphenyldiol
• Empirical Formula (Hill Notation): C₁₈H₁₈O₂
• CAS Number: 528-43-8
• Molecular Weight: 266.33
• MDL number: MFCD00016658
• UNSPSC Code: 12352100
• PubChem Substance ID: 24896843
• NACRES: NA.25

Properties

• biological source: plant
• Quality Level: 200
• assay: ≥90% (HPLC)
• solubility: ethanol: soluble 1 mg/mL; methanol: soluble 1.5 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; fungi
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O
• InChI: 1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
• InChI key: VVOAZFWZEDHOOU-UHFFFAOYSA-N

Description

General description

Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees.[1] It has a hydroxylated bi-phenoid structure[2] like that of its structural isomer honokiol.[3] It is a lipophilic compound.[2]

Application

Magnolol has been used:

• to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model[2]
• to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay[4]
• to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains[5]
• in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies[6]

Biochem/physiol Actions

Magnolol exerts anti-depressant[7] and, neurodegenerative properties.[8] It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis.[1]

Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.

Safety Information

• pictograms: GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H315,H318,H335,H411
• pcodes: P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves