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M3633

Sigma-Aldrich

4-Methylumbelliferyl β-D-glucopyranoside

β-glucosidase substrate

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Synonym(s):
MUD
Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
Molecular Weight:
338.31
Beilstein:
94672
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Assay

≥99% (HPLC)

form

powder

solubility

DMF: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λex 316 nm; λem 372 nm (pH 9.1)
λex 360 nm; λem 449 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16-/m1/s1

Inchi Key

YUDPTGPSBJVHCN-YMILTQATSA-N

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This Item
M7633M9766M9659
form

powder

form

powder

form

powder

form

powder

solubility

DMF: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless to very faintly yellow

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λex 316 nm; λem 372 nm (pH 9.1), λex 360 nm; λem 449 nm (Reaction product)

fluorescence

λex 317 nm; λem 374 nm (pH 9.1), λex 360 nm; λem 449 nm (Reaction product)

fluorescence

-

fluorescence

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

Application

4-Methylumbelliferyl β-D-glucopyranoside has been used as substrate:
  • in glucosylceramidase β enzyme activity assay in lysosome-enriched fractions from primary hippocampal neurons
  • in β-glucosidase assay during yeast fermentation
  • to assay glucocerebrosidase 1 (GBA1)-related glucosidase activity in macrophage cell line (RAW)

Biochem/physiol Actions

4-Methylumbelliferyl β-D-glucopyranoside is a synthetic enzymatic substrate for glycosidase. It has been used as substrate for the β- glucosidase from enterococci.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Assessing microbial safety of drinking water improving approaches and methods: Improving approaches and methods, 253-253 (2003)
HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Tol MJ, et al.
Autophagy, 14(3), 437-449 (2018)
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations
Li H, et al.
Autophagy, 15(1), 113-130 (2019)
Samantha G Scharenberg et al.
Nature communications, 11(1), 3327-3327 (2020-07-06)
Gaucher disease is a lysosomal storage disorder caused by insufficient glucocerebrosidase activity. Its hallmark manifestations are attributed to infiltration and inflammation by macrophages. Current therapies for Gaucher disease include life-long intravenous administration of recombinant glucocerebrosidase and orally-available glucosylceramide synthase inhibitors.
A Rashidi et al.
Bone marrow transplantation, 51(12), 1561-1564 (2016-08-16)
Post-transplant cyclophosphamide (PT-Cy) is the backbone of GvHD prophylaxis following haploidentical hematopoietic cell transplantation (haplo-HCT). PT-Cy has also been used in matched related (MRD) and unrelated (MUD) settings. It is not known whether outcomes are similar between haplo-HCT and MRD/MUD

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