All Photos(1)

M3781

Sigma-Aldrich

6α-Methylprednisolone 21-hemisuccinate sodium salt

lyophilized powder

Synonym(s):
MPSL, 6α-Methylprednisolone sodium succinate, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate
Linear Formula:
C26H33O8Na
CAS Number:
Molecular Weight:
496.53
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

synthetic

sterility

non-sterile

assay

≥98.00% (TLC)

form

lyophilized powder

application(s)

toxicology assay: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

Gene Information

human ... NR3C1(2908)

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Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Matthias D'Hondt et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 69(3), 232-240 (2012-01-21)
The short-term stability of extemporaneously prepared triple intrathecal therapy, containing cytarabine, methotrexate sodium, and methylprednisolone sodium succinate, was evaluated. Three batches of triple intrathecal solution were prepared using commercially available products and stored in three different packaging materials (plastic syringe
Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells
Zou W, et al.
Journal of Bone and Mineral Metabolism, 33(6), 615-624 (2015)
Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy.
Sabrina Fourcade et al.
Archives of dermatology, 147(10), 1227-1228 (2011-10-19)
Acute liver failure and aplastic anemia in an 11-year-old girl.
Ann Ming Yeh et al.
Digestive diseases and sciences, 56(8), 2237-2240 (2011-03-29)
Julio Urrutia et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 16(4), 439-442 (2011-04-30)
The effect of corticosteroids on spinal fusion healing has not yet been determined. To evaluate the effect of corticosteroids on lumbar spinal fusion we designed a randomized, placebo-controlled animal study using high-dose methylprednisolone sodium succinate, which is widely used in

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