Skip to Content
MilliporeSigma

M3824

α-Mangostin

≥98% (HPLC)

Synonym(s):

α-MG, alpha-Mangostin

Slide 1 of 4
Sign In to View Organizational & Contract Pricing.

Select a Size

Pricing and availability is not currently available.

About This Item

Empirical Formula (Hill Notation):
C24H26O6
CAS Number:
6147-11-1
Molecular Weight:
410.46
NACRES:
NA.25
PubChem Substance ID:
329817982
UNSPSC Code:
12352212
EC Number:
448-420-7
MDL number:
MFCD00135200

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

α-Mangostin, ≥98% (HPLC)

InChI key

GNRIZKKCNOBBMO-UHFFFAOYSA-N

InChI

1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3

SMILES string

COc1c(O)cc2Oc3cc(O)c(C\C=C(\C)C)c(O)c3C(=O)c2c1C\C=C(/C)C

assay

≥98% (HPLC)

form

powder

solubility

methanol: 1 mg/mL, clear, very light yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

Quality Level

200

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
PHL89247M6824A7883
α-Mangostin ≥98% (HPLC)

Sigma-Aldrich

M3824

α-Mangostin

Mangostin phyproof® Reference Substance

PHL89247

Mangostin

gamma-Mangostin ≥98% (HPLC)

Sigma-Aldrich

M6824

gamma-Mangostin

5α-Androst-16-en-3α-ol

Sigma-Aldrich

A7883

5α-Androst-16-en-3α-ol

form

powder

form

-

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

food and beverages

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

-

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

solubility

methanol: 1 mg/mL, clear, very light yellow

solubility

-

solubility

methanol: 1 mg/mL, colorless to yellow

solubility

ethanol: 19.60-20.40 mg/mL, clear, colorless

Application

α-Mangostin has been used:
  • to study its protective effect against oxidative stress mediated-retinal cell death[1]
  • to study its role as an antigenotoxic agent in DNA protection against oxidative damage[2]
  • to understand its anti-bacterial activity against Staphylococcus epidermidis RP62A[3]

Biochem/physiol Actions

α-Mangostin displays various pharmacological properties both in in vitro and in vivo studies.[4] These include antimicrobial, anticarcinogenic, antidiabetic, neuroprotective, hepatoprotective[5] and anti-inflammatory properties.[6]
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory.
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.

General description

α-Mangostin (α-MG) is the most abundant phytochemical derived from the pericarp of Garcinia mangostana L..[5] It is a tetraoxygenated diprenylated xanthone.[7] The chemical structure of α-MG molecule is 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)- 9H-xanthen-9-one.[7]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
WXBF2536V
WXBF0975V
WXBD6883V
WXBD5557V
WXBD2826V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Aungkana Krajarng et al.
Research in veterinary science, 93(2), 788-794 (2012-02-22)
Osteosarcoma is the most frequently diagnosed primary bone tumor in dog. Since chemotherapeutics are quite limited due to high cost and severe toxicity, therefore, the ultimate goal is to discover cost-effective therapeutics with less toxicity. We have studied the effect
Murugesan Sivaranjani et al.
Frontiers in microbiology, 10, 150-150 (2019-02-23)
Background: Alpha-mangostin (α-MG) is a natural xanthone reported to exhibit rapid bactericidal activity against Gram-positive bacteria, and may therefore have potential clinical application in healthcare sectors. This study sought to identify the impact of α-MG on Staphylococcus epidermidis RP62A through
Ali Ghasemzadeh et al.
Molecules (Basel, Switzerland), 23(8) (2018-07-26)
Since α-mangostin in mangosteen fruits was reported to be the main compound able to provide natural antioxidants, the microwave-assisted extraction process to obtain high-quality α-mangostin from mangosteen pericarp (Garcinia mangostana L.) was optimized using a central composite design and response
Xiaofang Quan et al.
PloS one, 7(3), e33376-e33376 (2012-03-20)
α-Mangostin, isolated from the hulls of Garcinia mangostana L., was found to have in vitro cytotoxicity against 3T3-L1 cells as well as inhibiting fatty acid synthase (FAS, EC 2.3.1.85). Our studies showed that the cytotoxicity of α-mangostin with IC(50) value
Jeremy J Johnson et al.
Carcinogenesis, 33(2), 413-419 (2011-12-14)
There is a need to characterize promising dietary agents for chemoprevention and therapy of prostate cancer (PCa). We examined the anticancer effect of α-mangostin, derived from the mangosteen fruit, in human PCa cells and its role in targeting cell cycle-related
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service