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M3895

Sigma-Aldrich

Mucin from bovine submaxillary glands

Type I-S

Synonym(s):
MUC
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

bovine submaxillary glands

Quality Level

type

Type I-S

form

powder

composition

Bound sialic acids, 9-24%

technique(s)

electrophoresis: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

cow ... BSM(286841)

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This Item
A7517M1778M2378
Bovine Serum Albumin For use as a marker in SDS-PAGE

Sigma-Aldrich

A7517

Bovine Serum Albumin

form

powder

form

lyophilized powder

form

partially purified powder

form

powder

technique(s)

electrophoresis: suitable

technique(s)

electrophoresis: suitable

technique(s)

microbiological culture: suitable

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P98091

UniProt accession no.

P02769

UniProt accession no.

-

UniProt accession no.

A0A5G2QSD1

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Gene Information

cow ... BSM(286841)

Gene Information

bovine ... ALB(280717)

Gene Information

-

Gene Information

pig ... MUC2(100127145)

General description

Mucin from bovine submaxillary glands is encoded by two bovine submaxillary BSM genes. It is present in the saliva and interacts with air and food. Mucin comprises three major domains namely N- and C terminal and the glycosylated proline, threonine and serine (PTS domain) central domain. The sialic acid contributes to 30% of the molecular weight of mucin. The central domain has many tandem repeats.

Application

Mucin from bovine submaxillary glands has been used:
  • in the quantification of mucin
  • as a component of artificial tear solution
  • as a substrate for recombinant sialidase Gardnerella vaginalis
  • to investigate a galactose-specific lectin from the red marine alga Ptilota filicina
  • to study the characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa)

Biochem/physiol Actions

Bovine submaxillary mucin (BSM) is thermally stable up to 85°C. The terminal domain regions are key for the adsorption functionality of mucin.
Albuminoid substance in mucus which gives it its ropy consistency

Linkage

Similar to M 4503, but produced by Sigma.

Substrates

Neuraminidase substrate.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

A H Sampaio et al.
Phytochemistry, 48(5), 765-769 (1998-07-17)
A lectin from the red marine alga Ptilota filicina (PFL) was isolated by affinity chromatography on cross-linked guar gum. PFL agglutinated native and papain-treated human erythrocytes with preference for type O erythrocytes. The lectin was inhibited by galactose and its
Proteolytic degradation of bovine submaxillary mucin (BSM) and its impact on adsorption and lubrication at a hydrophobic surface
Madsen JB, et al.
Langmuir, 31(30), 8303-8309 (2015)
Instability and breakup of model tear films
Bhamla MS, et al.
Investigative Ophthalmology & Visual Science, 57(3), 949-958 (2016)
The central domain of bovine submaxillary mucin consists of over 50 tandem repeats of 329 amino acids: Chromosomal localization of the BSM1 gene and relations to ovine and porcine counterparts
Jiang W, et al.
European Journal of Biochemistry, 267(8), 2208-2217 (2000)
Investigation of the thermostability of Bovine Submaxillary Mucin (BSM) and its impact on lubrication
Madsen JB, et al.
APCBEE procedia, 7, 21-26 (2013)

Articles

Sialic Acid

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