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M3946

Sigma-Aldrich

Anti-MNK1 antibody produced in rabbit

~1.4 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-MAPK signal-integrating serine/threonine kinase 1
NACRES:
NA.44

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~40 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1.4 mg/mL

technique(s)

western blot: 1-2 μg/mL using lysates of HEK-293T cells transfected with human Mnk1

UniProt accession no.

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MKNK1(8569)

General description

MNK1 is a serine-threonine kinase that is activated by ERK or p38 MAPK signaling cascades and modulates translation through eIF4E phosphorylation. Human MNK1 has two C-terminal splice variants, namely, MNK1a and MNK1b. While MNK1a is expressed in the cytoplasm, MNK1b is mainly localized at the nucleus . Anti-MNK1 antibody is specific for human Mnk1 (40 kDa). In immunoblotting, staining of the Mnk1 band is specifically inhibited by the immunizing peptide.

Immunogen

synthetic peptide corresponding to amino acids 12-27 of human MNK1, conjugated to KLH.

Application

Anti-MNK1 antibody is suitable for use in western blot (1-2 μg/mL using lysates of HEK-293T cells transfected with human Mnk1).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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