M4145

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

• Synonym(s): 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Empirical Formula (Hill Notation): C₉H₁₅N₅O
• CAS Number: 38304-91-5
• Molecular Weight: 209.25
• EC Number: 253-874-2
• MDL number: MFCD00063409
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277853
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥99% (TLC)
• mp: 272-274 °C (dec.) (lit.)
• originator: Johnson & Johnson
• SMILES string: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
• InChI key: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Gene Information: human ... KCNJ1(3758)

Description

Application

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Biochem/physiol Actions

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves