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M4263

Sigma-Aldrich

Malonyl coenzyme A lithium salt

≥90% (HPLC)

Synonym(s):

Malonyl CoA lithium salt

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$154.00


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5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00

About This Item

Empirical Formula (Hill Notation):
C24H38N7O19P3S · xLi+
CAS Number:
Molecular Weight:
853.58 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

$154.00


In StockDetails


assay

≥90% (HPLC)

form

powder

solubility

H2O: soluble 50 mg/mL protein, clear, colorless

storage temp.

−20°C

SMILES string

[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O

InChI

1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);

InChI key

OPIJLICRFQMMJH-UHFFFAOYSA-N

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1 of 4

This Item
685518A2181C6146
solubility

H2O: soluble 50 mg/mL protein, clear, colorless

solubility

-

solubility

H2O: soluble 100 mg/mL, clear, colorless

solubility

-

assay

≥90% (HPLC)

assay

97% (CP)

assay

≥93% (HPLC)

assay

≥90% (HPLC)

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

powder

form

solid

form

powder

form

powder

Application

Malonyl coenzyme A lithium salt has been used:
  • in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay[1]
  • in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase[2]
  • as an internal standard in the reaction mixture used for succinyl-CoA ligase assay[3]

Biochem/physiol Actions

Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.[4]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Questions

1–2 of 2 Questions  
  1. whats the appropriate solvent? PBS? DMSO? DW?

    1 answer
    1. As reported in the PROPERTIES section, this product is soluble in H2O at 50 mg/mL yielding a clear, colorless solution.

      Helpful?

  2. Malonyl Coenzyme A can be store as aqueous solution ?

    1 answer
    1. The stability of Malonyl Coenzyme A in aqueous solution has not been determined. However, other sources indicate that prepared solutions may be stable for several months at a minimum of -20 °C.

      Helpful?

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