As reported in the PROPERTIES section, this product is soluble in H2O at 50 mg/mL yielding a clear, colorless solution.
M4263
Malonyl coenzyme A lithium salt
≥90% (HPLC)
Synonym(s):
Malonyl CoA lithium salt
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5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00
$154.00
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5 MG
$154.00
10 MG
$295.00
25 MG
$591.00
100 MG
$1,880.00
About This Item
Empirical Formula (Hill Notation):
C24H38N7O19P3S · xLi+
CAS Number:
Molecular Weight:
853.58 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
$154.00
In StockDetails
Recommended Products
assay
≥90% (HPLC)
form
powder
solubility
H2O: soluble 50 mg/mL protein, clear, colorless
storage temp.
−20°C
SMILES string
[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
InChI
1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);
InChI key
OPIJLICRFQMMJH-UHFFFAOYSA-N
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Related Categories
1 of 4
This Item | 685518 | A2181 | C6146 |
|---|---|---|---|
| solubility H2O: soluble 50 mg/mL protein, clear, colorless | solubility - | solubility H2O: soluble 100 mg/mL, clear, colorless | solubility - |
| assay ≥90% (HPLC) | assay 97% (CP) | assay ≥93% (HPLC) | assay ≥90% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form solid | form powder | form powder |
Application
Malonyl coenzyme A lithium salt has been used:
- in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay[1]
- in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase[2]
- as an internal standard in the reaction mixture used for succinyl-CoA ligase assay[3]
Biochem/physiol Actions
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.[4]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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whats the appropriate solvent? PBS? DMSO? DW?
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Malonyl Coenzyme A can be store as aqueous solution ?
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The stability of Malonyl Coenzyme A in aqueous solution has not been determined. However, other sources indicate that prepared solutions may be stable for several months at a minimum of -20 °C.
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