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M4603

Sigma-Aldrich

Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10

≥95% (HPLC)

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Synonym(s):
SHU9119
Empirical Formula (Hill Notation):
C54H71N15O9
Molecular Weight:
1074.24
MDL number:
NACRES:
NA.32

Quality Level

Assay

≥95% (HPLC)

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... POMC(5443)

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β-Endorphin human ≥95% (HPLC)

Sigma-Aldrich

E6261

β-Endorphin human

UniProt accession no.

P01189

UniProt accession no.

P01189

UniProt accession no.

P01189

UniProt accession no.

P01189

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

Gene Information

human ... POMC(5443)

Gene Information

human ... POMC(5443)

Gene Information

human ... POMC(5443)

Gene Information

human ... POMC(5443)

Amino Acid Sequence

Ac-Nle-cyclo(Asp-His-Nal-Arg-Trp-Lys-NH2)

Biochem/physiol Actions

Screening analogs of the cyclic lactam melanocortin agonist MTII led to the identification of the agoutimimetic SHU9119. This compound shares pharmacological properties with the agouti peptide in that it is a potent antagonist of the melanocortin-4 receptor and a less potent antagonist of the melanocortin-3 receptor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Anna Fosch et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely
V J Hruby et al.
Journal of medicinal chemistry, 38(18), 3454-3461 (1995-09-01)
The cloning of the melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) receptors (MC1-R and MC2-R, respectively) recently has led to the identification of three additional melanocortin receptors, MC3-R, MC4-R, and MC5-R. The MC2 receptor primarily recognizes only ACTH peptides, but
W Fan et al.
Nature, 385(6612), 165-168 (1997-01-09)
Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone

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