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M5441

Sigma-Aldrich

Mibefradil dihydrochloride hydrate

≥98% (HPLC), powder

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Synonym(s):
(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate
Empirical Formula (Hill Notation):
C29H38FN3O3 · 2HCl · xH2O
CAS Number:
Molecular Weight:
568.55 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: soluble >20 mg/mL
absolute ethanol: insoluble

originator

Roche

SMILES string

O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C

InChI

1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1

InChI key

IZSWBBGKLWFDOC-YKXHUFBBSA-N

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This Item
D6196U111SML0042
Lazabemide hydrate ≥97% (HPLC)

Sigma-Aldrich

SML0042

Lazabemide hydrate

form

powder

form

powder

form

solid

form

powder

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

desiccated

color

white

color

white to off-white

color

white

color

white to tan

solubility

H2O: soluble >20 mg/mL, absolute ethanol: insoluble

solubility

H2O: ≥10 mg/mL

solubility

H2O: 13 mg/mL

solubility

DMSO: ≥22 mg/mL

originator

Roche

originator

-

originator

-

originator

Roche

Application

Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

Biochem/physiol Actions

Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels. It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.
Ro 40-5967 is a T-type Ca2+ channel blocker; antihypertensive.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Slide 1 of 9

1 of 9

Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons
McDonough S I and Bean B P
Molecular Pharmacology, 54(6), 1080-1087 (1998)
Bobbi-Jo Lowie et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G835-G845 (2011-08-13)
Interstitial cells of Cajal associated with the myenteric plexus (ICC-MP) are pacemaker cells of the small intestine, producing the characteristic omnipresent electrical slow waves, which orchestrate peristaltic motor activity and are associated with rhythmic intracellular calcium oscillations. Our objective was
Mibefradil block of cloned T-type calcium channels
Martin R L, et al.
Journal of Pharmacology and Experimental Therapeutics, 295(1), 302-308 (2000)
Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers
Mullins M E, et al.
JAMA : The Journal of the American Medical Association, 280(2), 157-158 (1998)
Calcium channels are involved in EphB/ephrinB reverse signaling-induced apoptosis in a rat chronic ocular hypertension model
Dong L, et al.
Molecular Medicine Reports, 17(2), 2465-2471 (2018)

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