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M5883

7-Methylguanosine 5′-diphosphate sodium salt

≥92.5%, synthetic (organic), powder

Synonym(s):

7-Methyl-gdp, m7GDP

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$407.00
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About This Item

Empirical Formula (Hill Notation):
C11H17N5O11P2 · xNa+
CAS Number:
104809-16-7
Molecular Weight:
457.23 (free acid basis)
MDL number:
MFCD00057869
UNSPSC Code:
41106305
PubChem Substance ID:
329818024
NACRES:
NA.51

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Product Name

7-Methylguanosine 5′-diphosphate sodium salt, ≥92.5%

biological source

synthetic (organic)

Quality Level

200

assay

≥92.5%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

storage temp.

−20°C

SMILES string

[Na+].[Na+].C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13

InChI

1S/C11H17N5O11P2.2Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

InChI key

VSMXIKIFPKDZJA-IDIVVRGQSA-L

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This Item
I4375T9375A5763
7-Methylguanosine 5′-diphosphate sodium salt ≥92.5%

Sigma-Aldrich

M5883

7-Methylguanosine 5′-diphosphate sodium salt

Inosine 5′-diphosphate sodium salt ≥96%

Sigma-Aldrich

I4375

Inosine 5′-diphosphate sodium salt

Thymidine 5′-diphosphate sodium salt ≥96% (HPLC)

Sigma-Aldrich

T9375

Thymidine 5′-diphosphate sodium salt

Adenosine 3′,5′-diphosphate disodium salt ≥96%

Sigma-Aldrich

A5763

Adenosine 3′,5′-diphosphate disodium salt

biological source

synthetic (organic)

biological source

microbial

biological source

synthetic (organic)

biological source

synthetic (inorganic)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

assay

≥92.5%

assay

≥96%

assay

≥96% (HPLC)

assay

≥96%

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 25 mg/mL, clear, colorless to very faintly yellow

General description

7-Methylguanosine 5′-diphosphate (m7GDP) is derived when the human decapping Dcp2 enzyme cleaves the cap of the deadenylated mRNAs during the 5′–3′ mRNA decay pathway. [1]

Application

7-Methylguanosine 5′-diphosphate sodium salt has been used as a component of the elution buffer for the purification of 5’capped RNA.[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000460744
0000460744
0000368195
0000368195
SLCJ5789

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Susan Parrish et al.
Journal of virology, 81(23), 12973-12978 (2007-09-21)
Vaccinia virus (VACV) encodes enzymes that cap the 5' end of viral mRNAs, which enhances their stability and translation. Nevertheless, recent studies demonstrated that the VACV D10 protein (VACV-WR_115) decaps mRNA, an enzymatic activity not previously shown to be encoded
A Step-by-Step Procedure to Analyze the Efficacy of siRNA Using Real-Time PCR
Cheng A, et al.
Methods in Molecular Biology, 419, 303-316 (2008)
DcpS can act in the 5??3? mRNA decay pathway in addition to the 3??5? pathway
Erwin VD, et al.
Proceedings of the National Academy of Sciences, 100(21) (2003)
7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by Decapping Scavenger (DcpS) enzymes and potently inhibits their activity
Wypijewska A, et al.
Biochemistry, 51(40) (2012)
H Matsuo et al.
Nature structural biology, 4(9), 717-724 (1997-09-26)
eIF4E, the mRNA cap binding protein, is a master switch that controls eukaryotic translation. To be active, it must bind eIF4G and form the eIF4F complex, which also contains eIF4A. Translation is downregulated by association of eIF4E with 4E-BP, which
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