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M6013

Sigma-Aldrich

Medroxyprogesterone

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Synonym(s):
17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione, 17α-Hydroxy-6α-methylprogesterone, 6α-Methyl-5-pregnen-17α-ol-3,20-dione, 6-Dihydromegestrol
Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
Molecular Weight:
344.49
Beilstein/REAXYS Number:
2510965
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

assay

≥98% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O

InChI

1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1

InChI key

FRQMUZJSZHZSGN-HBNHAYAOSA-N

Gene Information

rat ... Ar(24208)

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1 of 4

This Item
H5752P9521P8629
Medroxyprogesterone

M6013

Medroxyprogesterone

17α-Hydroxyprogesterone ≥95%

H5752

17α-Hydroxyprogesterone

21-Deoxycortisol

P9521

21-Deoxycortisol

5β-Pregnane-3α,17α,20α-triol

P8629

5β-Pregnane-3α,17α,20α-triol

assay

≥98% (HPLC)

assay

≥95%

assay

≥98.00% (TLC)

assay

≥98.00% (TLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

solubility

ethanol: 9.80-10.20 mg/mL, clear, colorless

solubility

chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless

Gene Information

rat ... Ar(24208)

Gene Information

human ... PGR(5241), SERPINA6(866)
rat ... Ar(24208)

Gene Information

-

Gene Information

-

Caution

Much of the pharmacology literature refers to medroxyprogesterone acetate as medroxyprogesterone, but they are of course not the same substance.

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Description
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pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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James Hassell et al.
Hormones and behavior, 60(2), 219-225 (2011-06-04)
Progestins and antiprogestins are widely used therapeutic agents in humans. In many cases, these are indicated for the treatment of reproductive activities. However, progesterone has widespread physiological effects including a reduction of the response to stress. We have reported that
A Günzel-Apel et al.
Reproduction in domestic animals = Zuchthygiene, 47 Suppl 6, 55-60 (2013-01-04)
Progesterone profiles of individual bitches may vary considerably both between and within individuals during pregnancy and non-pregnancy. Suspected luteal deficiency is commonly purported but is difficult to evaluate in clinical cases when progesterone is supplemented because this masks the underlying
The role of medroxyprogesterone acetate (MPA) in the treatment of renal adenocarcinoma.
M Kjaer
Cancer treatment reviews, 15(3), 195-209 (1988-09-01)
P C Schwallie
Contraception, 23(4), 375-386 (1981-04-01)
Data from published studies of the quantity of medroxyprogesterone acetate and/or its metabolites in the milk of lactating women receiving Depo-Provera for contraception is extrapolated into the amount of drug ingested daily by a theoretically average infant. Comparisons are made
Kevin D Beck et al.
Neurobiology of learning and memory, 97(1), 148-155 (2011-12-06)
Ovarian hormones modulate acquisition processes involved in classical conditioning. Although progesterone has been indirectly implicated, its role in classical conditioning of the eyeblink response has not been directly investigated. We assessed the effects of daily dosing of progesterone or medroxyprogesterone

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