M6020

Sigma-Aldrich

D-(+)-Mannose

powder, BioReagent, suitable for cell culture

Synonym(s):
D-Mannopyranose
Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
Molecular Weight:
180.16
Beilstein/REAXYS Number:
1564373
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75
Pricing and availability is not currently available.

biological source

plant (Spruce, Birch or Beech Wood, Glucose)

Quality Level

product line

BioReagent

assay

≥99%

form

powder

application(s)

cell culture | mammalian: suitable

mp

133-140 °C (lit.)

solubility

H2O: 50 mg/mL

Featured Industry

Agriculture

SMILES string

OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6?/m1/s1

InChI key

WQZGKKKJIJFFOK-QTVWNMPRSA-N

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General description

Mannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration. Majority of mannose is synthesised from its epimer glucose. It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.

Application

D-(+)-Mannose has been used:
  • as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersa
  • as a medium component for the selection of P898012 sorgum seeds transfected with Agrobacterium
  • in segmented filamentous bacterium (SFB) medium supplement for culturing human cell lines

Mannose is an aldohexose carbohydrate. This product may be used to study the effects of exogenous mannose on in vitro processes such as glycosylation.

Packaging

25, 100, 500 g in poly bottle

Biochem/physiol Actions

Mannose may be used to study the effects of exogenous mannose on in vitro processes such as glycosylation. cis-Golgi glycoproteins have high mannose and are prone to Endoglycosidase H or peptide N-glycosidase (N-glycanase) digestion.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Metabolic manipulation of glycosylation disorders in humans and animal models
Freeze HH and Sharma V
Seminars in Cell & Developmental Biology, 21(6), 655-662 (2010)
Agrobacterium-mediated transformation of Sorghum bicolor using immature embryos
Transgenic Plants, 109-122 (2012)
Growth and host interaction of mouse segmented filamentous bacteria in vitro
Schnupf P, et al.
Nature, 520(7545), 99-100 (2015)
Derek Thomson et al.
Pulmonary pharmacology & therapeutics, 40, 69-79 (2016-05-26)
It is now recognized that certain polysaccharides can exhibit anti-inflammatory activity, including the glycosaminoglycan (GAG) heparin that is widely used as an anti-coagulant drug. However, it would be desirable to identify molecules that retain the anti-inflammatory actions of heparin, but...
Golgi glycosylation
Stanley P
Cold Spring Harbor Perspectives in Biology, 3(4), a005199-a005199 (2011)

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