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M6559

Sigma-Aldrich

Anti-Matrix Metalloproteinase-24, Cytoplasmic antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

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Synonym(s):
Anti-MMP-24, Anti-MT5-MMP
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen 65 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

flow cytometry: suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1:2,000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MMP24(10893)
mouse ... Mmp24(17391)

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This Item
M6684SAB2101491
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

200

Quality Level

200

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

rabbit

UniProt accession no.

Q9Y5R2

UniProt accession no.

Q9Y5R2

UniProt accession no.

Q9Y5R2

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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General description

Matrix metalloproteinase-24 (MMP-24) is mainly expressed in the nervous system and also in the lungs, kidneys and liver. It is a 64kDa protein whose gene is localized on human chromosome 20.

Specificity

Reacts with native and reduced MMP-24. The antibody recognizes the pro-form of MMP-24 as well as activation/breakdown products. The cytoplasmic domain of MMP-24 is detached when MT-MMPs shed from themselves, thus this antibody should not detect this form of MMP-24.

Immunogen

synthetic peptide corresponding to the cytoplasmic domain of mouse matrix metalloproteinase-24 (membrane-type matrix metalloproteinase-5)

Biochem/physiol Actions

Matrix metalloproteinase-24 (MMP-24) is involved in the conversion of pro-matrix metalloproteinase-2 to its functional active form. It may be important for brain development and studies have shown that it is overexpressed in gastric cancer.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids


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A M Romanic et al.
American journal of physiology. Renal physiology, 281(2), F309-F317 (2001-07-18)
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade the extracellular matrix (ECM). The membrane-type matrix metalloproteinases (MT-MMPs) are a new family of MMPs that differ from other MMPs in that they have a transmembrane domain that anchors
Heather H Ross et al.
FEBS letters, 581(30), 5923-5928 (2007-12-08)
Membrane-type 5 matrix metalloproteinase (MT5-MMP) expression is ubiquitous in brain development while restricted to regions of neuroplasticity in adult. In the multipotent NT2 model of neurogenesis and differentiation, MT5-MMP is differentially expressed with significantly higher mRNA levels in the differentiated
E Llano et al.
Cancer research, 59(11), 2570-2576 (1999-06-11)
A cDNA encoding a new member of the membrane-type (MT) matrix metalloproteinase (MMP) family has been identified and cloned from a human brain cDNA library. The isolated cDNA encodes a polypeptide of 645 amino acids that displays a similar domain
Sol de la Peña et al.
Disease markers, 2014, 285906-285906 (2014-03-29)
During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. To analyze the

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