Documents

M6692

Sigma-Aldrich

Monoclonal Anti-Minor Vault Protein 193 antibody produced in mouse

250 μg/mL, clone p193-4, tissue culture supernatant

Synonym(s):
Anti-p193, Anti-VPARP
MDL number:
NACRES:
NA.41

Quality Level

biological source

mouse

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

p193-4, monoclonal

species reactivity

human

concentration

250 μg/mL

application(s)

immunocytochemistry: 1:10-1:20 using 4% paraformaldehyde-fixed cytospin preparation
immunohistochemistry (frozen sections): 1:10-1:20
western blot (chemiluminescent): 1:10-1:20

isotype

IgG1κ

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PARP4(143)

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General description

Minor vault protein 193 is also known as poly (ADP-ribose) polymerase family member 4 (PARP4). Along with two other proteins, it is part of vaults (ribonucleoprotein particles present in the cytoplasm). The molecular weight of this protein is 193kDa.

Specificity

Reacts with an internal epitope of (aa 491-494, HPGE) of p193.

Immunogen

E. coli lysate transformed with the pET28a(+) expression vector containing amino acids 408-611 of p193 cDNA.

Biochem/physiol Actions

Minor vault protein 193 is highly expressed in tumors.

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Certificate of Analysis

Certificate of Origin

The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.
Kickhoefer VA
The Journal of Cell Biology, 146(5), 917-928 (1999)
Formate assay in body fluids: application in methanol poisoning.
A B Makar et al.
Biochemical medicine, 13(2), 117-126 (1975-06-01)

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