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M6949

Sigma-Aldrich

Madecassoside from Centella asiatica

≥95% (HPLC)

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Synonym(s):
Madecassoside, Asiaticoside A, Redermic
Empirical Formula (Hill Notation):
C48H78O20
CAS Number:
Molecular Weight:
975.12
EC Number:
NACRES:
NA.25

Quality Level

Assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

H2O: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

InChI

1S/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3

InChI key

BNMGUJRJUUDLHW-UHFFFAOYSA-N

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1 of 4

This Item
A2612C9492G0549
Asiatic acid ≥98% (HPLC), from Centella asiatica

Sigma-Aldrich

A2612

Asiatic acid

form

powder

form

powder

form

powder

form

powder

color

white to off-white

color

white

color

-

color

-

solubility

H2O: 1 mg/mL, clear, colorless

solubility

methanol: 1 mg/mL, clear, colorless

solubility

-

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

-

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Madecassoside is one of the major pentacyclic triterpenoid saponin compounds extracted from Centella asiatica.

Application

Madecassoside has been used to study its cytotoxic effects on mouse macrophage cell lines (J774A.1). It has also been used as a potential inhibitor of serine racemase (SR) for in vitro and ex vivo studies.

Biochem/physiol Actions

Madecassoside has skin hydration properties. It is a well-known collagen inducer that exerts anti-aging and anti-rheumatoid arthritis effects. Madecassoside also elicits neuroprotective activities.
Madecassoside is a triterpenoid compound found in Centella asiatica (Gotu kola), a medicinal herb used in traditional Chinese medicine (TCM), Ayurvedic medicine, and traditional African medicine. Madecassoside has a wide range of reported biological activities including, anti-inflammatory, wound healing, and anti-oxidant activities. It has been reported to suppress LPS-induced TNF-alpha production via inhibition of ERK, p38, and NF-kappaB activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Asiaticoside United States Pharmacopeia (USP) Reference Standard

USP

1043331

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Sigma-Aldrich

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Sigma-Aldrich

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Paeoniflorin

Neoandrographolide analytical standard

Supelco

49879

Neoandrographolide

Harpagoside analytical standard

Supelco

68527

Harpagoside

Andrographolide analytical standard

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90281

Andrographolide

Rutin trihydrate analytical standard

Supelco

78095

Rutin trihydrate

Mei Liu et al.
Planta medica, 74(8), 809-815 (2008-05-20)
The current study was designed to investigate the effect of madecassoside, the major triterpene in CENTELLA ASIATICA, on burn wound healing and its possible mechanism of action. An oral administration of madecassoside (6, 12, 24 mg/kg) facilitated wound closure in
Guangtao Jia et al.
Journal of chromatography. A, 1193(1-2), 136-141 (2008-05-07)
In present study, the performance and separation characteristics of five macroporous resins for the enrichment and purification of asiaticoside and madecassoside from Centella asiatica extracts have been evaluated. The adsorption and desorption properties of total triterpene saponins (80% purity) on
The effects of individual and combination of asiatic acid and madecassoside derived from Centella asiatica (Linn.) on the viability percentage and morphological changes of mouse macrophage cell lines (J774A. 1)
Harun N H, et al.,
Journal of Applied Pharmaceutical Science, 8(11), 109-115 (2018)
Difei Bian et al.
Journal of biochemical and molecular toxicology, 26(10), 399-406 (2012-07-26)
This study aimed to investigate the effect of madecassoside against oxidative stress-induced injury of endothelial cells. Hydrogen peroxide (H(2)O(2), 500 µmol/L) was employed as an inducer of oxidative stress in human umbilical vein endothelial cells (HUVECs). Cell apoptosis was detected
F Bonté et al.
Annales pharmaceutiques francaises, 53(1), 38-42 (1995-01-01)
Type I and III collagens are the major components of skin dermis. Skin aging is related mainly to a decrease in type I collagen levels. Collagen I also plays an important role in wound healing. An enzyme-linked immunosorbent assay (ELISA)

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