M7033

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

• Synonym(s): N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt
• Empirical Formula (Hill Notation): C₇H₁₆N₄O₂ · C₂H₄O₂
• CAS Number: 53308-83-1
• Molecular Weight: 248.28
• Beilstein/REAXYS Number: 6674255
• MDL number: MFCD00069311
• UNSPSC Code: 12352209
• PubChem Substance ID: 24278043
• NACRES: NA.77

Properties

• Product Name: N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)
• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• SMILES string: CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• InChI key: IKPNWIGTWUZCKM-JEDNCBNOSA-N
• Gene Information: human ... NOS1(4842), NOS2(4843), NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Nos1(24598), Nos2(24599)

Description

Application

N^G-Methyl-L-arginine acetate salt has been used:

• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice[1]
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells[2]
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay[3]

Biochem/physiol Actions

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages.[4] It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine.[5] It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.[6]

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)