This product is lyophilized from mouse ascites fluid. The total protein content is verified prior to lyophilization. The 15 mg/mL value is the pre-lyophilization total protein content. The Myeloma Protein-Densitometry is performed after lyophilization when reconstituted to 1ml in water. The 5 mg value is specific to the Myeloma Protein (IgG1 kappa) only.
M7894
IgG1, Kappa from murine myeloma
clone MOPC 21, ascites fluid, lyophilized powder
Synonym(s):
Mouse IgG1-κ
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5 MG
$420.00
5 X 5 MG
$1,570.00
About This Item
Conjugate:
unconjugated
Clone:
MOPC 21, monoclonal
Application:
—
Citations:
39
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biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
clone
MOPC 21, monoclonal
form
lyophilized powder
application(s)
research pathology
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
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1 of 4
This Item | M9269 | I3784 | M3795 |
|---|---|---|---|
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| clone MOPC 21, monoclonal | clone MOPC 21, monoclonal | clone DX, monoclonal | clone TEPC 183, monoclonal |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form ascites fluid | antibody form purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified immunoglobulin |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form lyophilized powder | form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
General description
The MOPC-21 tumor line that produces mouse IgG1, κ is a mineral oil induced plasmacytoma originated and carried intraperitoneally in BALB/c mice. Immunoglobulins G are made up of two identical light chains and two identical heavy chains, that are covalently connected by interchain disulphide bonds.[1] Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b, IgG2c and IgG3.[2]
Application
Biochem/physiol Actions
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids. It provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.[8]
Preparation Note
Reconstitute with 1 mL deionized water.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Eva Obermueller et al.
Cancer research, 64(21), 7801-7812 (2004-11-03)
Tumor growth and progression are critically controlled by alterations in the microenvironment often caused by an aberrant expression of growth factors and receptors. We demonstrated previously that tumor progression in patients and in the experimental HaCaT tumor model for skin
J Zhu et al.
American journal of respiratory and critical care medicine, 164(12), 2220-2228 (2001-12-26)
We wished to determine if the inflammatory cells surrounding the airway mucus-secreting glands in chronic bronchitis (CB) were associated with interleukin (IL)-4 and IL-5 mRNA expression and whether the CD8 T cell population expressed these cytokines. Digoxigenin-labeled IL-4 and IL-5
M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis
Schlapbach LJ, et al.
Pediatric Research, 71(4-1), 368-368 (2012)
IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
Lederle W, et al.
International Journal of Cancer. Journal International Du Cancer, 128(12), 2803-2814 (2011)
GM-CSF enhances tumor invasion by elevated MMP-2,-9, and-26 expression
Gutschalk CM, et al.
Cancer Medicine, 2(2), 117-129 (2013)
Related Content
Datasheet
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Good morning, I have a question about product specification. Looks like 1vial contains about 5mg and the protein, correct? What does the 15mg/ml protein by Biuret info mean? Because if the reconstitution is done in 1mL, the highest conc. is 5mg/mL, no? Ty
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