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M8631

Sigma-Aldrich

Melanin

Synthetic

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CAS Number:
EC Number:
MDL number:
NACRES:
NA.83

form

powder

storage temp.

−20°C

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3

InChI key

XUMBMVFBXHLACL-UHFFFAOYSA-N

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This Item
PHR1274M2659M2649
Sigma-Aldrich

Sigma-Aldrich

M8631

Melanin

Melamine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1274

Melamine

Melamine 99%

Sigma-Aldrich

M2659

Melamine

storage temp.

−20°C

storage temp.

2-30°C

storage temp.

-

storage temp.

−20°C

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

200

General description

Melanin is a vital pigment present on the surface structures of vertebrates, which contribute to skin color. It has three forms such as, eumelanin, pheomelanin and neuromelanin. Melanin has cation chelating and redox properties. It is a potent absorbent of light. Melanin functions as a chemoprotective and photoprotective pigment. Mutations in this gene are associated with oculocutaneous albinism, vitiligo, piebaldism and Waardenburg syndrome.

Application

Melanin has been used:
  • in spectrophotometry
  • to study its effect on reverse transcription polymerase chain reaction (RT-PCR) inhibition and effect of BSA (bovine serum albumin) in overcoming the inhibition
  • as an absorber for skin layer in near-infrared tissue spectra
  • Raman spectroscopy

Preparation Note

Prepared by oxidation of tyrosine with hydrogen peroxide.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Zheng Wang et al.
Frontiers in microbiology, 4, 379-379 (2014-01-01)
Melanization due to the inactivation of the homogentisate-1,2-dioxygenase gene (hmgA) has been demonstrated to increase stress resistance, persistence, and virulence in some bacterial species but such pigmented mutants have not been observed in pathogenic members of the Vibrio Harveyi clade.
Danielle J Harper et al.
Journal of biophotonics, 12(12), e201900153-e201900153 (2019-07-25)
Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization properties (using polarization sensitive OCT). However, these methods are only suitable
Removal of analyte-irrelevant variations in near-infrared tissue spectra
Yang Y, et al.
Applied Spectroscopy, 60(9), 1070-1077 (2006)
Miguel J Beltrán-García et al.
PloS one, 9(3), e91616-e91616 (2014-03-22)
In pathogenic fungi, melanin contributes to virulence, allowing tissue invasion and inactivation of the plant defence system, but has never been implicated as a factor for host cell death, or as a light-activated phytotoxin. Our research shows that melanin synthesized
Diorders of Pigmentation
Zaidi Z, et al.
Treatment of Skin Diseases, 159-170 (2019)

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