The solubility of this product is tested in 1N NH4OH. Melanin is soluble in alkaline solutions and is expected to be soluble in both KOH and NaOH solutions.
M8631
Melanin
Synthetic
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100 MG
$127.00
250 MG
$215.00
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$648.00
About This Item
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Product Name
Melanin, Synthetic
SMILES string
[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
InChI key
XUMBMVFBXHLACL-UHFFFAOYSA-N
InChI
1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
form
powder
storage temp.
−20°C
Quality Level
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1 of 4
This Item | M0418 | 8.08614 | 52549 |
|---|---|---|---|
| form powder | form powder | form powder | form - |
| Quality Level 100 | Quality Level - | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. no temp limit | storage temp. - |
Application
General description
Melanin is a vital pigment present on the surface structures of vertebrates,[5] which contribute to skin color.[6] It has three forms such as, eumelanin, pheomelanin and neuromelanin.[6] Melanin has cation chelating and redox properties. It is a potent absorbent of light. Melanin functions as a chemoprotective and photoprotective pigment. Mutations in this gene are associated with oculocutaneous albinism, vitiligo, piebaldism and Waardenburg syndrome.[5]
Preparation Note
Prepared by oxidation of tyrosine with hydrogen peroxide.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Removal of analyte-irrelevant variations in near-infrared tissue spectra
Yang Y, et al.
Applied Spectroscopy, 60(9), 1070-1077 (2006)
Diorders of Pigmentation
Zaidi Z, et al.
Treatment of Skin Diseases, 159-170 (2019)
Miguel J Beltrán-García et al.
PloS one, 9(3), e91616-e91616 (2014-03-22)
In pathogenic fungi, melanin contributes to virulence, allowing tissue invasion and inactivation of the plant defence system, but has never been implicated as a factor for host cell death, or as a light-activated phytotoxin. Our research shows that melanin synthesized
Bovine serum albumin reverses inhibition of RT-PCR by melanin
Giambernardi TA, et al.
Biotechniques, 25(4), 564-566 (1998)
Melanin
Riley PA
The International Journal of Biochemistry & Cell Biology, 29(11), 1235-1239 (1997)
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Is it soluble in KOH and NaOH?
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Can this product be dissolved in water?
1 answer-
Product M8631 is not tested for solubility in water. The solubility is tested in 1N NH4OH at 20 mg/ml.
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We have used this melanin product. Is it known whether it is in oxidized form? Any information about the exact chemical structure ?
1 answer-
This synthetic melanin product was prepared by oxidation of tyrosine with hydrogen peroxide.
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