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M8750

Sigma-Aldrich

(+)-Methamphetamine hydrochloride

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Synonym(s):
d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride
Empirical Formula (Hill Notation):
C10H15N · HCl
CAS Number:
Molecular Weight:
185.69
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H2O: soluble
ethanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originator

Teva

SMILES string

Cl[H].CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

InChI key

TWXDDNPPQUTEOV-FVGYRXGTSA-N

Gene Information

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This Item
1399001M6267B8263
Methamphetamine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1399001

Methamphetamine hydrochloride

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

solubility

H2O: soluble, ethanol: soluble

solubility

-

solubility

H2O: soluble

solubility

-

originator

Teva

originator

-

originator

-

originator

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

pharmaceutical (small molecule)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
veterinary

Gene Information

human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Gene Information

human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Gene Information

-

Gene Information

human ... SLC18A2(6571)

Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Features and Benefits

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be
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International journal of molecular sciences, 22(13) (2021-07-03)
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Leila Rezaeian et al.
Iranian journal of basic medical sciences, 23(11), 1480-1488 (2020-11-26)
This research aimed at evaluating the effect of berberine hydrochloride on anxiety-related behaviors induced by methamphetamine (METH) in rats, assessing relapse and neuroprotective effects. 27 male Wistar rats were randomly assigned into groups of Control, METH-withdrawal (METH addiction and subsequent
G J Rivière et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)
The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3
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ACS chemical neuroscience, 10(8), 3622-3634 (2019-07-10)
Methamphetamine (METH) is a globally abused, highly addictive stimulant. While investigations of the rewarding and motivational effects of METH have focused on neuronal actions, increasing evidence suggests that METH can also target microglia, the innate immune cells of the central

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