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Key Documents

M9191

Sigma-Aldrich

Microsomes from Liver, Pooled

from rat(Sprague-Dawley), female

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

biological source

rat (Sprague-Dawley)

Quality Level

form

liquid

specific activity

≥20 units/mg protein, pH 7.4, 37 °C

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

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Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Unit Definition

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.
7-ethoxyresorufin O-deethylase activity: One unit will hydroxylate 1.0 picomole paclitaxel per minute at pH 7.4 at 37 deg C.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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