M9441
Microsomes from Liver, Pooled
from mouse(CD-1), male
Synonym(s):
lab equipment accessory
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 vial | 0 left in stock | $137.00 |
About This Item
NACRES:
NA.47
UNSPSC Code:
12161501
Biological source:
mouse (CD-1)
biological source
mouse (CD-1)
Quality Level
form
liquid
packaging
vial of ~10 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... Mgst1(56615)
General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
Application
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.[1]
Biochem/physiol Actions
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Source of drug metabolizing enzymes, including cytochrome P-450.
1 of 1
This Item | |||
|---|---|---|---|
| biological source mouse (CD-1) | biological source mouse (CD-1) | biological source rat (Sprague-Dawley) | biological source human |
| Gene Information mouse ... Mgst1(56615) | Gene Information mouse ... Mgst1(56615) | Gene Information - | Gene Information - |
| form liquid | form liquid | form liquid | form - |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Related Content
Instructions
AQ-4, a deuterium-containing molecule, acts as a microtubule-targeting agent for cancer treatment
Lin BY, et al.
European Journal of Pharmacology, 173093-173093 (2020)
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.
Lu AY and Coon MJ
The Journal of Biological Chemistry, 243(6), 1331-1332 (1968)
Liver microsomes; an integrated morphological and biochemical study.
PALADE GE
The Journal of Biophysical and Biochemical Cytology, 2(2), 171-200 (1956)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M9441-1VL | 04061838164193 |