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Key Documents

M9441

Sigma-Aldrich

Microsomes from Liver, Pooled

from mouse(CD-1), male

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

biological source

mouse (CD-1)

Quality Level

form

liquid

packaging

vial of ~10 mg

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Mgst1(56615)

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General description

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).

Application

Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents and tunicamycin.
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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