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MilliporeSigma

MSQC8

Sigma-Aldrich

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Antibody Cysteine-Fluorophore Conjugate Standard

Synonym(s):

Antibody Drug Conjugate

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0.5 MG
$786.00

About This Item

UNSPSC Code:
12352204
NACRES:
NA.32

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$786.00

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recombinant

expressed in CHO cells

Quality Level

200

antibody product type

primary antibodies

form

lyophilized powder

shipped in

wet ice

storage temp.

−20°C

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SigmaMAb Antibody Drug Conjugate (ADC) Mimic Antibody Cysteine-Fluorophore Conjugate Standard

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SILu™Lite SigmaMAb Universal Antibody Standard human

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SILu™Lite SigmaMAb Universal Antibody Standard human

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

form

lyophilized powder

form

solid

form

solid

form

-

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

antibody product type

primary antibodies

antibody product type

-

antibody product type

-

antibody product type

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000448819
0000448819
0000428925
0000428559
0000428559

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Questions

1–2 of 2 Questions  

  1. Is the primary sequence of the antibody available?

    1 answer

    1. SigmaMAb Antibody Drug Conjugate (ADC) Mimic consists of the human universal monoclonal antibody standard (Catalog Number MSQC4, an IgG1 monoclonal antibody) conjugated to dansyl fluorophores via an LC-SMCC crosslinker.

      The sequence of MSQC4 can be found in the user guide. Sequence Information:

      1. SigmaMAb Heavy Chain:
      EVQLVESGGGLVQPGGSLRLSCVASGFTLNNYD MHWVRQGIGKGLEWVSKIGTAGDRYYAGSVKGR FTISRENAKDSLYLQMNSLRVGDAAVYYCARGAG RWAPLGAFDIWGQGTMVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPG

      2. SigmaMAb Light Chain:
      QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNF VSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGS KSGNTASLTISGLQAEDEADYYCCSYAGDYTPGV VFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANK ATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT HEGSTVEKTVAPTECS

      Helpful?

  2. Does MSQC8 (SigmaMAb Antibody Drug Conjugate (ADC) Mimic) has light chain lambda or gamma?

    1 answer

    1. This antibody has both lambda light chains and gamma heavy chains.

      Helpful?

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