MTOX1005
MDR1/MRP2 Double Knockout Caco-2 Cells
Human male colorectal tissue, adenocarcinoma
Synonym(s):
C2BBe1 Cells MDR1/MRP2 (-/-/-/-,-/-/-/-)
About This Item
Recommended Products
product name
MDR1/MRP2 Double Knockout Caco-2 Cells, one vial
biological source
human male colorectal tissue (Source disease: adenocarcinoma)
Quality Level
form
liquid
technique(s)
drug transporter assay: suitable
permeability assay: suitable
application(s)
ADME/TOX
storage temp.
−196°C
Gene Information
human ... ABCB1(5243) , ABCC2(1244)
General description
Application
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
Features and Benefits
- A functional double knockout of the MDR1 gene and MRP2 gene eliminates the reliance on chemical inhibitors to determine if a compound is an BCRP substrate
- The vial format enables the MDR1 and MRP2 knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
Legal Information
Disclaimer
Kit Components Also Available Separately
- MTOX1005MDR1/MRP2 Double Knockout Caco-2 Cells, one vial 1 vialSDS
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Articles
We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
Utilize these Caco-2 cell based assay tools for screening small molecule drug compounds prior to clinical studies and submission to regulatory agencies.
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