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MilliporeSigma

N129

Sigma-Aldrich

Naloxone methiodide

≥98% (HPLC), solid

Synonym(s):

(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide

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25 MG
$103.55
100 MG
$328.00
250 MG
$682.00

About This Item

Empirical Formula (Hill Notation):
C20H24INO4
CAS Number:
Molecular Weight:
469.31
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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$103.55

List Price$109.00Save 5%
Web-Only Promotion

Estimated to ship onJuly 09, 2025Details


Request a Bulk Order
Technical Service
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Quality Level

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to tan

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChI key

ICONPJDAXITIPI-UXYWFNEESA-N

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This Item
N165N9412O003
form

solid

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

-

assay

≥96% (HPLC)

assay

-

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: >10 mg/mL

solubility

DMSO: soluble, H2O: soluble (with the addition of 0.1 N HCl), ethanol: soluble

solubility

DMSO: ~12 mg/mL, H2O: insoluble

solubility

H2O: 7.5 mg/mL (aqueous solutions should be promptly used), methanol: 7.6 mg/mL (do not store in ethanolic solution; methanolic solutions may be stored for several weeks at 4 °C)

Application

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice.[1] Naloxone methiodide has been used to block opioid neurotransmission.[2]

Biochem/physiol Actions

Naloxone methiodide has low affinity for opioid receptors than naloxone.[3] Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.[4]
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


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