N151

Nisoxetine hydrochloride

Name: Nisoxetine hydrochloride
Brand: SIGMA
Price: 416 USD

≥98% (HPLC), Norepinephrine reuptake inhibitor, solid

Synonym(s):

(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₁NO₂ · HCl

CAS Number:

57754-86-6

Molecular Weight:

307.82

MDL number:

MFCD00153850

UNSPSC Code:

12352200

PubChem Substance ID:

24277788

NACRES:

NA.77

Key Documents

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Product Name

Nisoxetine hydrochloride, solid, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

solubility

H₂O: 20 mg/mL
ethanol: 50 mg/mL

SMILES string

Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2

InChI

1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H

InChI key

LCEURBZEQJZUPV-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item	T7947	SML0474	B016
Sigma-Aldrich N151 Nisoxetine hydrochloride	Sigma-Aldrich T7947 (R)-Tomoxetine hydrochloride	Sigma-Aldrich SML0474 (S)-Duloxetine hydrochloride	Sigma-Aldrich B016 Benoxathian hydrochloride
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay -
form solid	form solid	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: 20 mg/mL, ethanol: 50 mg/mL	solubility -	solubility H₂O: 5 mg/mL (clear solution, warmed)	solubility H₂O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.), ethanol: soluble, isopropanol: soluble
storage condition desiccated	storage condition -	storage condition desiccated	storage condition -
color white to beige	color -	color white to beige	color white

Application

Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies.[1][2] It has also been used as a NET blocker to study its effects on perivascular adipose tissue.[3]

Biochem/physiol Actions

Nisoxetine is a selective and potent noradrenaline reuptake inhibitor.[4] It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.[5]

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000293783

042M4604V

0000144840

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A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.

Ching-I A Wang et al.

Molecular pharmacology, 82(5), 898-909 (2012-08-10)

The human norepinephrine transporter (NET) is implicated in many neurological disorders and is a target of tricyclic antidepressants and nisoxetine (NX). We used molecular docking simulations to guide the identification of residues likely to affect substrate transport and ligand interactions

[3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding.

S M Tejani-Butt

The Journal of pharmacology and experimental therapeutics, 260(1), 427-436 (1992-01-01)

The uptake sites for norepinephrine (NE) in brain have not been studied in much detail, probably due to the absence of an adequate radioligand for labeling these sites. This study describes the binding properties of [3H]nisoxetine to uptake sites for

Current status of the biogenic amine theory of depression.

B E Leonard

Neurochemistry international, 4(5), 339-350 (1982-01-01)

An attempt has been made to assess critically the clinical and experimental evidence that implicates a malfunctioning of amine neurotransmitter systems in the aetiology of depression. The evidence available does provide indirect evidence in favour of the biogenic amine theory

Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease.

Adjmal Nahimi et al.

International review of neurobiology, 141, 251-274 (2018-10-14)

Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of

Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.

Jacob P R Jacobsen et al.

Psychopharmacology, 199(2), 137-150 (2008-05-23)

Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses. The objective of this study was to explore whether insensitivity to selective serotonin reuptake inhibitors (SSRIs) in NMRI

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Nisoxetine hydrochloride