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N158

Sigma-Aldrich

Naftopidil hydrochloride hydrate

solid

Synonym(s):

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611

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25 MG
$247.00

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25 MG
$247.00

About This Item

Empirical Formula (Hill Notation):
C24H28N2O3 · xHCl · yH2O
CAS Number:
57149-07-2
Molecular Weight:
392.49 (anhydrous free base basis)
MDL number:
MFCD11046013
UNSPSC Code:
12352200
PubChem Substance ID:
24277790
NACRES:
NA.77

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form

solid

Quality Level

200

color

white

solubility

methanol: >10 mg/mL
H2O: insoluble

SMILES string

O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34

InChI

1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2

InChI key

INIDYCYXDNFBSV-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Biochem/physiol Actions

α1-Adrenoceptor antagonist; antihypertensive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000329583
0000329566
SLCM9335
SLCL0010
SLBQ0653V

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Tomokazu Sazuka et al.
Journal of endourology, 26(9), 1216-1220 (2012-04-11)
To examine the efficacy of an alpha-1 blocker and its correlation to structural alteration of the prostatic urethra and the loss of energy in the urine flow using a virtual urethra processed from an endoscopic video image. Video images of
Katsumi Kadekawa et al.
Life sciences, 92(20-21), 1024-1028 (2013-04-16)
Alpha1D-adrenoceptors (α1D-ARs) located in the spinal cord are involved in the control of lower urinary tract function. In order to clarify the effect of α1D-ARs on storage function in the spinal cord, we examined the effect of oral administration and
Xiawen Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 140-145 (2012-10-03)
Two bioanalytical HPLC methods (chiral solid phases (CSPs) HPLC and pre-column derivatization HPLC) were developed and validated for the determination of naftopidil enantiomers in rat plasma. Analytes were extracted from biomaterials by liquid-liquid extraction. The pre-column derivatization HPLC method employed
G Sponer et al.
Journal of cardiovascular pharmacology, 20(6), 1006-1013 (1992-12-01)
The interaction of naftopidil with adrenoceptors was studied in comparison to standard drugs. Naftopidil binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidil, 0.43 nM for prazosin, and 197 nM for urapidil. The affinities of naftopidil
S Yamada et al.
Life sciences, 50(2), 127-135 (1992-01-01)
Binding properties of naftopidil and alpha 1-adrenoceptor antagonists to alpha-adrenoceptors in prostates from benign prostatic hypertrophy (BPH) were characterized by radioreceptor assays using [3H]prazosin and [3H]rauwolscine. Specific binding of [3H]prazosin and [3H]rauwolscine in human prostatic membranes was saturable and of
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